Observational Evaluation of Sertaconazole Nitrate Cream 2% in the Treatment of Pruritus Related to Tinea Pedis

Tinea pedis typically presents as a pruritic, erythematous, and scaly eruption on the foot, with symptoms correlated with the severity of infection. Although many clinical studies have assessed the antifungal action of various agents, relatively little attention has been devoted to evaluating if antifungal agents are capable of improving subjective symptoms while treating the infection. A single-center, open-label, observational, proof of concept study was conducted in 21 participants (age range, 16–74 years) to evaluate if sertaconazole nitrate cream 2% used twice daily for 7 days was able to reduce participants’ perceived itching while treating the infection. Findings included participants’ overall assessment of quality of life (QOL) with the Dermatology Life Quality Index (DLQI) and participants’ overall satisfaction with treatment. The pruritus visual analog scale (VAS) was used to assess the subjective symptom of itching. Results indicated the mean total score of changes in perception of QOL was 8.95 at baseline and 3.38 at day 7, a within-group change of –5.57 (P