Chondroid Syringoma

We present the case of a 25-year-old man who presented with a slowly enlarging nodule on the upper lip. This nodule first appeared after minor trauma to the area. Our original differential diagnosis included foreign body granuloma, mucocele, inclusion cyst, and adnexal tumor. Histopathology results showed an encapsulated tumor consisting of 2 discrete lobules composed of numerous aggregates of cuboid epithelial cells with tubuloalveolar structures and keratinous cysts within a chondroid stroma—consistent with a chondroid syringoma. We compare and contrast the clinical and histologic characteristics of chondroid syringomas (arising from sweat glands) with those of pleomorphic adenomas (arising from salivary glands).