Leukocytoclastic Vasculitis Induced by Use of Glyburide: A Case of Possible Cross-Reaction of a Sulfonamide and a Sulfonylurea

Drug-induced leukocytoclastic vasculitis (LCV) may present as the result of a single offending agent or more uncommonly, from a cross-reaction with a related medication. We describe a patient with sulfonamide allergy who developed LCV after exposure to a sulfonylurea. Sulfur-containing drugs may cross-react to induce LCV in susceptible individuals.