During the physiologic adaptation to dry terrestrial life, newborns may develop a range of cutaneous entities due to undeveloped adnexal structures, maternal hormone stimulation, or other unknown mechanisms. Rarely, cutaneous lesions may be indicators of underlying systemic diseases or congenital syndromes. Dr. Brooke Walls discusses neonatal skin and reviews skin disorders that may impact newborns. Most of these conditions are benign and are known to resolve spontaneously without treatment, but they are important to recognize.