Pyoderma Gangrenosum and Tumor Necrosis Factor α Agents

Pyoderma gangrenosum (PG) is a rare, ulcerative, neutrophilic, noninfectious dermatosis of unknown etiology seen in 1% to 5% of patients with inflammatory bowel disease (IBD). It has been reported in all age groups but usually affects women aged 40 to 60 years. Pyoderma gangrenosum often is associated with systemic diseases in approximately 50% of patients affected; however, it is not considered a manifestation or complication of these diseases and its clinical course usually is unrelated to the disease severity or activity.