The diabetic group had higher fasting plasma glucose levels, hepatic insulin resistance, and liver fat content at baseline, and experienced significant reductions into the normal range in all of these measures by 8 weeks, whereas values remained unchanged in the control group.
Pancreatic triacylglycerol content changed minimally in the control group (from 5.1% to 5.5%), but it fell significantly in the diabetic patients (from 6.6% to 5.4%, corresponding to loss of about 0.6 g of fat; P less than .005), according to Dr. Taylor, who disclosed that he had no relevant conflicts of interest.
In addition, the diabetic group had a significant increase in the first-phase insulin response to a stepped intravenous glucose infusion to normal levels (P less than .005), whereas the control group had no change.