Previous guidelines on reaching HbA1c had been developed to reduce micro- and macrovascular complications; however, evidence that lowering levels also would lower events was not substantial enough to prove correct, as results were limited to reductions in less serious complications, according to Dr. Ende.
Dr. Jack Ende
Physicians whose patients have HbA1c levels less than 6.5% are advised to deintensify patients’ pharmacologic therapy by reducing the dosage, or taking a medication out completely.
New guidelines were based on evaluation of four drug-therapy trials, which encompassed long- and short-term effects of intensive pharmacological therapy compared with more moderate treatment.