BOTTOM LINE
Interventions with some evidence of effectiveness for infantile colic include hypoallergenic diets and formula, soy formula, decreased infant stimulation, herbal tea, and dicyclomine (Bentyl). Reports of severe adverse effects of dicyclomine in infants younger than 7 weeks caused a black-box warning for use in those aged less than 6 months. The following interventions are essentially equal to or worse than placebo treatment: simethicone (Mylicon, Gas-X), scopolamine, lactase enzyme (Lactulose), fiber-enriched formula, increased carrying, car-ride simulators, and sucrose. (Level of evidence [LOE]=1a–)