An additional concern is the teratogenic effects of isotretinoin in patients with natal female internal genitalia. While these patients may not think they can get pregnant because of testosterone-associated amenorrhea, the potential is still present and pregnancy should be avoided, Dr. Campos-Munoz and her colleagues warned.
No funding or conflicts of interest were disclosed.
SOURCE: Campos-Munoz L et al. Pediatr Dermatol. 2018 Mar 25. doi: 10.1111/pde.13448.