But while oral coenzyme Q10 is a popular OTC treatment for statin-associated muscle complaints, it’s not supported by any good evidence. A meta-analysis of six randomized trials totaling 302 participants found coenzyme Q10 had no impact on symptoms (Mayo Clin Proc. 2015;90[1]:24-34).
In Dr. Paauw’s view, however, those trials didn’t address the proper question.
“The studies that have been done aren’t the right study,“ he said. “The study that needs to be done is for prevention: Do patients who start a statin and coenzyme Q10 at the same time stay on the statin and feel better?”
He reported having no financial conflicts of interest regarding his presentation.