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New AAP ADHD Guideline Expands Age Range, Scope

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Recs for Preschoolers Add Value to Guideline

The expansion of the AAP ADHD clinical practice guideline to include recommendations for preschool-age children is one of a number of welcome and beneficial changes to help guide the management of patients with ADHD, according to Dr. David O. Childers.

"I’m really glad to see that they are endorsing identification and intervention in 4- to 5-year-olds. That has been practiced, but it really hasn’t been endorsed or considered an official standard of care," he said.

Furthermore, the recommendation to start with behavior therapy in this age group, moving to treatment with methylphenidate only if necessary, is a good strategy, he said, noting that the updated guideline recognizes – importantly – that while methylphenidate is off label for this indication, strong evidence exists showing that it has a better safety and efficacy profile for younger children than the only FDA-approved medication (dextroamphetamine) for ADHD in children under age 6 years.

Dr. Childers also praised the subcommittee’s decision to highlight the potential for substance abuse in adolescents with ADHD as well as the importance of obtaining assent in the adolescent population, the comorbidities associated with ADHD, the importance of evaluating younger children in more than one setting to assess symptoms, the value of behavior therapy strategies, the strength of the evidence for stimulant versus other types of medications in 6- to 11-year-olds, the chronic nature of ADHD, and the need for medication dose titration to "best effect – not first effect."

One thing he said he would have liked to have seen included is a greater emphasis on the DSM-IV’s requirement that children be assessed based on their developmental level. A child with language delay, for example, will have an attention level commensurate with their language skills rather than their age, therefore an assessment that doesn’t take this into consideration could lead to a misdiagnosis, he explained.

Dr. Childers is assistant professor of pediatrics and chief of the division of developmental pediatrics at the University of Florida, Jacksonville. He said he had no relevant financial disclosures.


 

FROM PEDIATRICS

The updated guideline was developed in collaboration with several organizations whose representatives formed the working subcommittee. The group met over a 2-year period to review changes in practice that have occurred over time and issues that have been identified since the previous guideline were published. A multilevel systematic approach was used to identify the literature that built the evidence base for the diagnosis and treatment recommendations, which underwent extensive peer review by committees, sections, councils, and task forces within the AAP, as well as numerous outside groups and individuals. The guidelines will be reviewed and/or revised in 5 years, unless evidence emerges that warrants an earlier revision, they noted.

"As occurred with the initial guidelines, we hope the revised guidelines will provide the process that primary care clinicians treating children and youth can use to provide the best evidence-based practices for their patients who have or are suspected of having ADHD," Dr. Wolraich said.

Development of the new ADHD guideline was funded by the AAP with support from the Partnership for Policy Implementation initiative. Multiple subcommittee members reported financial disclosures, which are included in the Pediatrics article where the guideline is published. Dr. Wolraich, for example, reported that he has served periodically as a consultant to Shire, Eli Lilly, Shinogi, and Next Wave Pharmaceuticals. The article states that all conflicts were "resolved through a process approved by the AAP Board of Directors."

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