"More than 2 decades before any noticeable symptoms, pathophysiological changes are at work in patients who are destined to develop AD. This information may now provide us objective, identifiable outcomes with which to assess new therapies," said Dr. Caselli.
"Based upon the findings of Dr. Stefansson and his colleagues, it’s easy to imagine how a new BACE1 inhibitor could be applied to a preclinical Alzheimer’s population, with outcomes measured by the targets identified by Dr. Bateman and his coauthors – perhaps catapulting us into a new age of prevention therapy for AD," he noted.