Conclusions
Completed trials suggest that depression care programs integrated into the primary care setting can improve depression and disability outcomes of patients with major and possibly minor depression. The completed research increases the public health imperative for refining understanding of how to provide depression care most effectively and cost-effectively and for determining the extent to which these interventions can benefit new patient populations and the societal benefits of such care programs. The completed trials have established a stronger basis for organized efforts to improve the quality of depression care in health care systems. They have also set the stage for both larger trials and meta-analyses of completed trials that are designed to answer key questions about the societal benefits of improved depression care.