Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Single-Fraction Radiation Misses Mark for Spinal Compression Relief

Publish date:: December 4, 2019

Key clinical point: Single-fraction radiation was not noninferior to 5-fraction radiation for treatment of spinal compression at 8 weeks.

Major finding: Among patients in the single-fraction arm, 69.3% had good ambulatory status at 8 weeks, vs. 72.7% of patients in the multi-fraction arm.

Study details: SCORAD trial, a randomized noninferiority trial of 686 patients with spinal compression from metastatic cancers.

Disclosures: Cancer Research UK and Cancer Council Queensland funded the trial. Dr. Hoskin reported being supported by the National Institute for Health Research Manchester Biomedical Research Centre.

Citation:

Hoskin PJ et al. JAMA 2019 Dec 3. doi: 10.1001/jama.2019.17913.

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