Case-Based Review

HER2-Positive Breast Cancer: Current Management


 

References

Conclusion

HER2-positive tumors represent a distinct subset(s) of breast tumors with unique pathological and clinical characteristics. Treatment with a combination of cytotoxic chemotherapy and HER2-targeted agents has led to a dramatic improvement in survival for patients with locoregional and advanced disease. Trastuzumab is an integral part of adjuvant therapy for HER2-positive invasive disease. Pertuzumab should be added to trastuzumab in node-positive disease. Neratinib may be considered after completion of trastuzumab therapy in patients with hormone receptor–positive disease. For metastatic HER2-positive breast cancer, a regimen consisting of docetaxel plus trastuzumab and pertuzumab is the standard first-line therapy. Ado-trastuzumab is an ideal next line option for patients whose disease progresses on trastuzumab and taxanes.

Pages

Recommended Reading

Female cancer researchers receive less funding than male counterparts
MDedge Hematology and Oncology
Adjuvant trastuzumab for breast cancer: 6 months may suffice
MDedge Hematology and Oncology
Oophorectomy for premenopausal breast cancer
MDedge Hematology and Oncology
CBT-I bests acupuncture for treating insomnia among cancer survivors
MDedge Hematology and Oncology
Screening for brain mets could improve quality of life for some with breast cancer
MDedge Hematology and Oncology
Ketorolac may reduce breast cancer recurrence risk, particularly in overweight patients
MDedge Hematology and Oncology
Dr Jame Abraham's top ASCO selections in breast cancer
MDedge Hematology and Oncology
Heading down the wrong pathway in advanced breast cancer?
MDedge Hematology and Oncology
TAILORx: Most women with intermediate risk ER+ breast cancer can safely skip chemo
MDedge Hematology and Oncology
PI3K inhibitor/fulvestrant has modest benefit, serious toxicity in breast cancer
MDedge Hematology and Oncology