Cellular Therapy
From the Journals
Managing CAR-T Neurotoxicity: EEG Bests the Rest
In managing the ICANS side effect, electroencephalogram is associated with greater therapeutic intervention versus MRI and lumbar puncture.
News
Secondary Cancers Post CAR T Therapy: A Concern?
FDA analysis of adverse events following CAR T-cell therapy reports on the incidence of secondary blood cancers.
News
Myeloma: FDA Advisers Greenlight Early CAR-T
ODAC voted 11-0 in support of expanded cilta-cel use, 8-3 for expanded ide-cel use, while urging clearer warning about the risks of these drugs....
News
FDA Approves First CAR T-Cell Therapy for rrCLL, rrSLL
For the first time, CAR T-cell therapy for treatment of relapsed/refractory CLL or SLL gets FDA approval.
Conference Coverage
High Marks for New CAR T Toxicity Grading Tool
A real-world study demonstrates the benefits of a new grading system to assess hematotoxicities across disease types following CAR T-cell...
Conference Coverage
B-ALL: CAR-T Outperforms Novel Therapies
Real-world patients with B-ALL who relapsed post transplant showed significantly better outcomes with CAR T-cell therapy versus novel alternative...
Conference Coverage
MM:New Tool Gauges Post–CAR T Relapse Risk
Key disease, treatment, and inflammation risk factors predict patients at a higher risk of relapse.
Commentary
Unleashing Our Immune Response to Quash Cancer
“It’s astounding how devious cancer cells and tumor tissue can be.”
Feature
CAR T-Cell: Do Benefits Still Outweigh Risks?
“Cautious reassurance” urged, as early reports suggest that the risks of secondary malignancies are similar to those of other cancer treatments....
Conference Coverage
Distinct toxicity profiles for anti-BCMA myeloma therapies
New FDA data analysis shows CAR T-cell and other anti-BCMA treatments for multiple myeloma are linked to considerable risks for side effects.
Conference Coverage
CAR T-Cell Therapy: Cure for Systemic Autoimmune Diseases?
New research suggests that CAR T-cell therapy might prove to be a game-changing treatment for lupus and two other autoimmune diseases.