Joint risk stratification that combined family history and genetic risk scores was compared with risks determined by each predictor. As the genetic risk score increased there was an observed increased risk for individuals with first-degree relatives, second-degree relatives, or without family history. Considering only genetic risk score, the increase in risk from the lowest to highest decile was 2.8-fold. In contrast, the increased risk from the lowest to highest decile was 6.14-fold when stratification included both genetic risk score and considering family history in first-degree relatives, thus demonstrating the enhancing effect of combining the independent relationship of these two predictors.
The investigators concluded from their results that, by combining the genetic risk scores with family history and other easy-to-collect risk factor information,
The authors reported that they had no conflicts of interest.
SOURCE: Weigl K et al. Clin Epidemiol. 2018;10:143-52.