About 9,000 alpha-blocker patients had a fracture versus 3,351 matched patients on other antihypertensives; “9,000 patients out of 70,000 is a huge number. These drugs are useful in some situations, but be careful,” Dr. Hiremath said.
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Dr. William Cushman
“This is observational data, but it’s consistent with ALLHAT, and the outcomes are even worse. We didn’t in [subsequent] guidelines say that you should [never] use an alpha-blocker in hypertension. Maybe we should have,” said ALLHAT investigator William Cushman, MD, a professor of medicine and physiology at the University of Tennessee, Memphis.
There was no industry funding for the work, and the investigators reported having no financial disclosures. Dr. Cushman wasn’t involved in the work.
SOURCE: Hiremath S et al. Joint Hypertension 2018, Abstract P375.