Antiplatelet agents are recommended over oral anticoagulation for patients with a noncardiac embolic stroke. Aspirin should not be combined with clopidogrel in this setting because of the increased risk of bleeding.
The full-text guideline contains additional recommendation statements of use to internists caring for patients who have had a prior TIA or stroke.
Reference. Furie KL, et al. Guidelines for the Prevention of Stroke in Patients with Stroke or Transient Ischemic Attack: A Guideline for Healthcare Professionals from the American Heart Association/American Stroke Association (Stroke 2011;42:227-76).