Article

Risk Alleles in Alzheimer Disease

Evaluating their effect

Publish date: October 20, 2015

 

References

There is an estimated 8% decrease in Alzheimer disease incidence without the CLU-MS4A4E risk alleles, according to a study of 3,837 patients with Alzheimer disease and 4,145 controls. Researchers found:

• Results support the CLU-MS4A4E interaction and a dominant effect.

• There is an association between CLU-MS4A4E and APOEɛ negative status.

• Estimated synergy factor for rs11136000-rs670139 is 2.23.

• Odds ratio for rs11136000-rs670139 is 2.45.

• Population attributable fraction (cPAF) for rs11136000-rs670139 is 8.0.

Citation: Ebbert MT, Boehme KL, Wadsworth ME, et al. Interaction between variants in CLU and MS4A4E modulates Alzheimer's disease risk. [Published online ahead of print October 5, 2015]. Alzheimers Dement. doi: 10.1016/j.jalz.2015.08.163.

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