Article

High disease activity during pregnancy tied to adverse pregnancy outcomes in RA


 

Key clinical point: The risk for preterm birth (PTB) and small for gestational age (SGA) is almost 2-fold higher in pregnant women with vs. without rheumatoid arthritis (RA), with high maternal RA disease activity during pregnancy being a significant risk factor.

Major finding: The risk for PTB (adjusted odds ratio [aOR] 1.92; 95% CI 1.56-2.35) and SGA (aOR 1.93; 95% CI 1.45-2.57) was significantly higher in RA pregnancies vs. control pregnancies, with the risk even higher with maternal Disease Activity Score in 28 joints-C-reactive protein of >4.1 vs. <3.2 during pregnancy (PTB: aOR 3.38; 95% CI 1.52-7.55; SGA: aOR 3.90; 95% CI 1.46-10.4).

Study details: This was a prospective cohort study of 1,739 RA-pregnancies matched with 17,390 control-pregnancies.

Disclosures: This study was supported by NordForsk and others. Some of the authors declared receiving consultancy fees, research grants, and serving on the steering committee for various sources.

Source: Hellgren K et al. Rheumatology (Oxford). 2021;keab894 (Dec 3). Doi: 10.1093/rheumatology/keab894 .

Recommended Reading

T-helper cell derangements tied to atrial fibrillation in RA
MDedge Rheumatology
Certolizumab seems effective as monotherapy in RA patients with failure to csDMARDs
MDedge Rheumatology
Obesity, depression, anxiety, and illness beliefs influence remission, pain, and fatigue in RA
MDedge Rheumatology
Similar long-term safety/tolerability of filgotinib 100 mg and 200 mg in moderate-to-severe RA
MDedge Rheumatology
Sinusitis and upper respiratory tract diseases may increase the risk for rheumatoid arthritis
MDedge Rheumatology
No impact of anti-inflammatory diet on health-related quality of life in RA
MDedge Rheumatology
Serum vitamin D level inversely tied to severe sarcopenia in females with RA
MDedge Rheumatology
Clinical Edge Journal Scan Commentary: RA December 2021
MDedge Rheumatology
RA patients treated with JAK inhibitors may need additional BNT162b2 COVID-19 vaccine boosts
MDedge Rheumatology
Factors predicting response to TNF inhibitors in RA
MDedge Rheumatology