It also may be that a different progestin may further reduce the CHD risk by inducing a better lipid profile, reducing plaque formation, and diminishing coronary artery reactivity and blood flow.
Clinical recommendation
These new data do not alter the current recommendation that HRT be used for the relief of disturbing vasomotor symptoms at the lowest effective dose and for the shortest tolerable time.7
However, we still have much to learn about the use of hormones in postmenopausal women, and need additional studies designed to allow us to develop the hormone regimen with the best safety and efficacy profile, which should be applied to the subgroups of postmenopausal women that will derive the most benefit.