Many medications are available in numerous dosage forms, which increases the risk of medication errors. To reduce dosing errors and avoid unnecessarily complex dosing, I suggest employing a “clinical reference dosing unit” (CRDU)—a basic reference dose expressed in milligrams that covers the typical dose range if administered as 1 to 4 pills.
CRDUs can help you and your patients remember a typical starting dose (1 pill), a target dose (2 or 3 pills), a high dose (4 pills), and a safe dose to make changes (1 pill). CRDUs also can help you track your prescribing because you can easily spot doses outside the usual range. For example, 8 pills indicate an unusually high dosage and a half pill might be too low.
Implementing CRDUs
Develop a list of CRDUs for the psychotropics you frequently prescribe. Note that the appropriate CRDU for a medication might vary among different clinical populations (Table). For any given medication use only 1 formulation, such as immediate-release or extended-release.
Monitor dosing by asking patients how many pills they take and when they take them.
Table
Sample CRDU prescribing of risperidone
| Patient population | CRDU (1 pill) | Dose range (1 to 4 pills) |
|---|---|---|
| First-episode psychosis patients | 1 mg | 1 to 4 mg |
| Chronic patients | 2 mg | 2 to 8 mg |
| Geriatric patients | 0.5 mg | 0.5 to 2 mg |
| CRDU: clinical reference dosing unit | ||
Patient education
Instruct your patients to initiate or change doses based on the number of pills, with 1 pill corresponding to the medication’s CRDU. For example, you might tell your patient, “Start with 1 pill at night for 1 week, then go up to 2 pills at night until you see me again.” Patients are more likely to correctly implement changes when instructions are based on the number of pills rather than on milligrams. Change the dosing to reach desired efficacy or increase tolerability by in-creasing or decreasing the number of pills or shifting the timing of the dosage, such as going from 1 pill twice daily to 2 pills at night.
Although CRDUs can be used for many antipsychotics, antidepressants, and anxiolytics, this method is not appropriate for medications that:
- are administered based on plasma levels or body weight, such as lithium or valproate
- do not have linear pharmacokinetics, such as phenytoin
- require a slower titration, such as clozapine.