Huntington's Disease
From the Journals
Progression in Huntington’s linked to CAG repeat number
The number of CAG trinucleotide repeats, which varies by individual, has long been linked to age at onset in Huntington’s disease; now...
From the Journals
Huntington’s symptom domains correlate with structural differences
From the Journals
Novel genetic therapy reduces key protein in Huntington’s disease
Intrathecal therapy was associated with dose-dependent reductions in mutant huntingtin protein, but clinical change will require further study.
Conference Coverage
Mutant huntingtin and neurofilament light are potential biomarkers in Huntington’s disease
PHILADELPHIA – The biomarkers successfully distinguish between healthy controls, patients with premanifest disease,...
Conference Coverage
Laquinimod may not improve motor function in Huntington’s disease
PHILADELPHIA – The drug raises no new safety concerns in patients with Huntington’s disease, compared with previous...
Literature Review
Polyglutamine diseases are rare, but not the mutations that cause them
A population-based study found more than 10% of European adults carried CAG repeats in the pathogenic range, despite lacking signs of disease.
Feature
Huntington’s research returns to Latin America, as scientists tread with care
Poor people in Latin America contributed to some of the biggest discoveries in Huntington’s disease research. Scientists want to work with them...
From the Journals
Huntington’s progression tracks with levels of mutant huntingtin, neurofilament light
Conference Coverage
VIDEO: Encouraging results reported for novel Huntington’s disease therapy
LOS ANGELES – In a short, 46-patient trial, the antisense oligonucleotide IONIS-HTTRx safely reduced CSF concentrations of the huntingtin protein...
Feature
Gene silencer reduces mutant huntingtin protein in early-stage Huntington’s patients
Whether reducing the mutant huntingtin protein with the antisense oligonucleotide IONIS-HTTRx helps patients remains to be seen.
Conference Coverage
Salivary biomarker identified for Huntington’s disease
SAN DIEGO – Perhaps the greatest potential is for predicting disease onset so treatments can be started before symptoms emerge.