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MADRID – A parental history of asthma or allergic rhinitis significantly increases the risk that a child will develop atopic dermatitis, and that risk doubles if a parent has a history of atopic dermatitis rather than another atopic disease, Nina H. Ravn reported at a meeting of the European Task Force on Atopic Dermatitis held in conjunction with the annual congress of the European Academy of Dermatology and Venereology.
She presented a comprehensive meta-analysis of 149 published studies addressing the risk of developing atopic dermatitis according to parental history of atopic disease. The studies included more than 656,000 participants. The picture that emerged from the meta-analysis was one of a stepwise increase in the risk of pediatric atopic dermatitis according to the type and number of parental atopic diseases present.
“This is something that hopefully can be useful when you talk with parents or parents-to-be with atopic diseases and they want to know how their disease might affect their child,” explained Ms. Ravn of the University of Copenhagen.
It’s also information that clinicians will find helpful in appropriately targeting primary prevention interventions if and when methods of proven efficacy become available. That’s a likely prospect, as this is now an extremely active field of research, she noted.
The meta-analysis showed that a parental history of atopic dermatitis was associated with a 3.3-fold greater risk of atopic dermatitis in the offspring than in families without a parental history of atopy. A parental history of asthma was associated with a 1.56-fold increased risk, while allergic rhinitis in a parent was linked to a 1.68-fold increased risk.
“It does matter what type of atopic disease the parents have,” she observed. “Those with a parental history of asthma or allergic rhinitis can be considered as being at more of an intermediate risk level, while those with a parental history of atopic dermatitis are a particularly high risk group.”
Of note, the risk of pediatric atopic dermatitis was the same regardless of whether the father or mother was the one with a history of atopic disease. If one parent had a history of an atopic disease, the pediatric risk was increased 1.3-fold compared to when the parental history was negative. If both parents had a history of atopic illness, the risk jumped to 2.08-fold. And if one parent had a history of more than one form of atopic disease, the pediatric risk of atopic dermatitis was increased 2.32-fold.
“An interesting result that was new to me what that fathers’ and mothers’ contribution to risk is equal,” said session cochair Andreas Wollenberg, MD, professor of dermatology at Ludwig Maximilian University of Munich. “For the past 2 decades we were always taught that the mother would have a greater impact on that risk.”
“I was also surprised by our findings,” Ms. Ravn replied. “But when we pooled all the data there really was no difference, nor in any of our subanalyses.”
She reported having no financial conflicts regarding her study.
SOURCE: Ravn NH. THE EADV CONGRESS.
MADRID – A parental history of asthma or allergic rhinitis significantly increases the risk that a child will develop atopic dermatitis, and that risk doubles if a parent has a history of atopic dermatitis rather than another atopic disease, Nina H. Ravn reported at a meeting of the European Task Force on Atopic Dermatitis held in conjunction with the annual congress of the European Academy of Dermatology and Venereology.
She presented a comprehensive meta-analysis of 149 published studies addressing the risk of developing atopic dermatitis according to parental history of atopic disease. The studies included more than 656,000 participants. The picture that emerged from the meta-analysis was one of a stepwise increase in the risk of pediatric atopic dermatitis according to the type and number of parental atopic diseases present.
“This is something that hopefully can be useful when you talk with parents or parents-to-be with atopic diseases and they want to know how their disease might affect their child,” explained Ms. Ravn of the University of Copenhagen.
It’s also information that clinicians will find helpful in appropriately targeting primary prevention interventions if and when methods of proven efficacy become available. That’s a likely prospect, as this is now an extremely active field of research, she noted.
The meta-analysis showed that a parental history of atopic dermatitis was associated with a 3.3-fold greater risk of atopic dermatitis in the offspring than in families without a parental history of atopy. A parental history of asthma was associated with a 1.56-fold increased risk, while allergic rhinitis in a parent was linked to a 1.68-fold increased risk.
“It does matter what type of atopic disease the parents have,” she observed. “Those with a parental history of asthma or allergic rhinitis can be considered as being at more of an intermediate risk level, while those with a parental history of atopic dermatitis are a particularly high risk group.”
Of note, the risk of pediatric atopic dermatitis was the same regardless of whether the father or mother was the one with a history of atopic disease. If one parent had a history of an atopic disease, the pediatric risk was increased 1.3-fold compared to when the parental history was negative. If both parents had a history of atopic illness, the risk jumped to 2.08-fold. And if one parent had a history of more than one form of atopic disease, the pediatric risk of atopic dermatitis was increased 2.32-fold.
“An interesting result that was new to me what that fathers’ and mothers’ contribution to risk is equal,” said session cochair Andreas Wollenberg, MD, professor of dermatology at Ludwig Maximilian University of Munich. “For the past 2 decades we were always taught that the mother would have a greater impact on that risk.”
“I was also surprised by our findings,” Ms. Ravn replied. “But when we pooled all the data there really was no difference, nor in any of our subanalyses.”
She reported having no financial conflicts regarding her study.
SOURCE: Ravn NH. THE EADV CONGRESS.
MADRID – A parental history of asthma or allergic rhinitis significantly increases the risk that a child will develop atopic dermatitis, and that risk doubles if a parent has a history of atopic dermatitis rather than another atopic disease, Nina H. Ravn reported at a meeting of the European Task Force on Atopic Dermatitis held in conjunction with the annual congress of the European Academy of Dermatology and Venereology.
She presented a comprehensive meta-analysis of 149 published studies addressing the risk of developing atopic dermatitis according to parental history of atopic disease. The studies included more than 656,000 participants. The picture that emerged from the meta-analysis was one of a stepwise increase in the risk of pediatric atopic dermatitis according to the type and number of parental atopic diseases present.
“This is something that hopefully can be useful when you talk with parents or parents-to-be with atopic diseases and they want to know how their disease might affect their child,” explained Ms. Ravn of the University of Copenhagen.
It’s also information that clinicians will find helpful in appropriately targeting primary prevention interventions if and when methods of proven efficacy become available. That’s a likely prospect, as this is now an extremely active field of research, she noted.
The meta-analysis showed that a parental history of atopic dermatitis was associated with a 3.3-fold greater risk of atopic dermatitis in the offspring than in families without a parental history of atopy. A parental history of asthma was associated with a 1.56-fold increased risk, while allergic rhinitis in a parent was linked to a 1.68-fold increased risk.
“It does matter what type of atopic disease the parents have,” she observed. “Those with a parental history of asthma or allergic rhinitis can be considered as being at more of an intermediate risk level, while those with a parental history of atopic dermatitis are a particularly high risk group.”
Of note, the risk of pediatric atopic dermatitis was the same regardless of whether the father or mother was the one with a history of atopic disease. If one parent had a history of an atopic disease, the pediatric risk was increased 1.3-fold compared to when the parental history was negative. If both parents had a history of atopic illness, the risk jumped to 2.08-fold. And if one parent had a history of more than one form of atopic disease, the pediatric risk of atopic dermatitis was increased 2.32-fold.
“An interesting result that was new to me what that fathers’ and mothers’ contribution to risk is equal,” said session cochair Andreas Wollenberg, MD, professor of dermatology at Ludwig Maximilian University of Munich. “For the past 2 decades we were always taught that the mother would have a greater impact on that risk.”
“I was also surprised by our findings,” Ms. Ravn replied. “But when we pooled all the data there really was no difference, nor in any of our subanalyses.”
She reported having no financial conflicts regarding her study.
SOURCE: Ravn NH. THE EADV CONGRESS.
REPORTING FROM The EADV CONGRESS
Key clinical point: Pediatric atopic dermatitis risk varies according to type of parental history of atopic disease.
Major finding: A parental history of atopic dermatitis is associated with a 3.3-fold increased risk of atopic dermatitis in the child, twice the risk associated with parental asthma or allergic rhinitis.
Study details: This was a systematic review and meta-analysis of 149 published studies with 656,711 participants.
Disclosures: The presenter reported having no financial conflicts regarding the study, conducted free of commercial support.
Source: Ravn NH. The EADV Congress.