Practice Alert

Clarifying the US Preventive Services Task Force’s 2005 recommendations

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The United States Preventive Services Task Force (USPSTF) is the most evidence-based and authoritative organization making recommendations on preventive services in the US. During 2005, 20 recommendations were made on a total of 10 conditions. TABLE 1 lists the recommendations made in 2005. TABLE 2 describes the criteria for the recommendations coming from the task force.

Several of these recommendations deserve elaboration.

TABLE 1
USPSTF recommendations made in 2005

A RECOMMENDATION (STRONGLY RECOMMENDS)
  • Prophylactic ocular topical medication for all newborns against gonococcal ophthalmia neonatorum.
  • Screening for HIV in all adolescents and adults at increased risk for HIV infection.
  • Screening all pregnant women for HIV.
B RECOMMENDATION (RECOMMENDS)
  • One-time screening for abdominal aortic aneurysm (AAA) by ultrasonography in men aged 65 to 75 who have ever smoked.
  • Referral for genetic counseling and evaluation for BRCA testing for women whose family history is associated with an increased risk for deleterious mutations in BRCA1 or BRCA2 genes.
  • Screening all sexually active women, including those who are pregnant, for gonorrhea infection if they are at increased risk for infection (that is, if they are young or have other individual or population risk factors.
C RECOMMENDATION (NO RECOMMENDATION FOR OR AGAINST)
  • Screening for AAA in men aged 65 to 75 who have never smoked.
  • Routine screening for HIV in adolescents and adults who are not at increased risk for HIV infection.
D RECOMMENDATION (RECOMMENDS AGAINST)
  • Routine screening for AAA in women.
  • Routine referral for genetic counseling or routine breast cancer susceptibility gene (BRCA) testing for women whose family history is not associated with an increased risk for deleterious mutations in breast cancer susceptibility gene 1(BRCA1) or breast cancer susceptibility gene 2 (BRCA2)
  • Routine screening for gonorrhea infection in men and women who are at low risk for infection.
  • Routine serological screening for herpes simplex virus (HSV) in asymptomatic pregnant women at any time during pregnancy to prevent neonatal HSV infection.
  • Routine serological screening for HSV in asymptomatic adolescents and adults.
  • Routine use of combined estrogen and progestin for the prevention of chronic conditions in postmenopausal women.
  • Routine use of unopposed estrogen for the prevention of chronic conditions in postmenopausal women who have had a hysterectomy.
  • Routine screening for peripheral arterial disease (PAD).
I RECOMMENDATION (INSUFFICIENT EVIDENCE TO RECOMMEND FOR OR AGAINST)
  • Screening adults for glaucoma.
  • Routine screening for gonorrhea infection in men at increased risk for infection.
  • Routine screening for gonorrhea infection in pregnant women who are not at increased risk for infection.
  • Routine screening for overweight in children and adolescents as a means to prevent adverse health outcomes.

TABLE 2
Meaning of recommendations by the USPSTF

A RECOMMENDATION: STRONGLY RECOMMENDS
The USPSTF found good evidence that the service improves important health outcomes and concludes that benefits substantially outweigh harms.
B RECOMMENDATION: RECOMMENDS
The USPSTF found at least fair evidence that the service improves important health outcomes and concludes that benefits outweigh harms.
C RECOMMENDATION: NO RECOMMENDATION FOR OR AGAINST
The USPSTF found at least fair evidence that the service can improve health outcomes but concludes that the balance of the benefits and harms is too close to justify a general recommendation.
D RECOMMENDATION: RECOMMENDS AGAINST
The USPSTF found at least fair evidence that the service is ineffective or that harms outweigh benefits.
I RECOMMENDATION: INSUFFICIENT EVIDENCE TO RECOMMEND FOR OR AGAINST
Evidence that the service is effective is lacking, of poor quality, or conflicting and the balance of benefits and harms cannot be determined.

Sexually transmitted infections

Among the conditions studied in 2005 were gonorrhea, herpes simplex virus (HSV), and human immunodefeciency virus (HIV). The recommendations were different for each. The task force strongly recommends (A recommendation) screening all pregnant women and all high-risk adolescents and adults for HIV. No recommendation is made regarding HIV screening in adolescents and adults who are not at high risk.

The task force recommends (B recommendation) screening high-risk women for gonorrhea, including those who are pregnant.

It recommends against (D recommendation) screening for gonorrhea in men and women at low risk and believes there is insufficient evidence (I recommendation) to advocate for or against screening men at high risk and pregnant women at low risk. It recommends against screening for HSV during pregnancy and among asymptomatic adolescents and adults.

The Task Force defines high risk a little differently for gonorrhea and HIV. These definitions are listed in TABLE 3.

What the C and I recommendations do and do not mean. Keep several points in mind regarding these recommendations. When no recommendation is made for or against (C recommendation), it signifies there is evidence of some benefit but not clear enough to outweigh harms. An I recommendation means that there is not enough quality evidence to make a recommendation. These 2 recommendations are often misinterpreted as a recommendation against the service, which they are not.

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