Neuro-oncology
From the Journals
Tandem transplants provide EFS edge in pediatric neuroblastoma
Patients randomized to tandem stem cell transplants after successful induction therapy had fewer events than patients assigned to single...
Literature Review
Treatment for pediatric low-grade glioma is associated with poor cognitive and socioeconomic outcomes
The risk for poor outcomes is greater when treatment includes radiotherapy, compared with surgery alone.
FDA/CDC
FDA approves bevacizumab-bvzr for several cancers
The bevacizumab biosimilar is now approved for metastatic colorectal cancer, advanced non-squamous non–small cell lung cancer, recurrent...
Conference Coverage
Liquid biopsy falls short for isolated brain lesions in lung cancer
GENEVA – Plasma circulating tumor DNA analysis detected molecular abnormalities in almost all patients with systemic...
From the Journals
Rituximab boosts survival in primary CNS lymphoma
The triplet combination of rituximab plus combination high-dose methotrexate and temozolomide could be a safe and effective first-line option for...
Literature Review
Virus-Specific T-Cell Infusions May Resolve Progressive Multifocal Leukoencephalopathy
Infusion of allogeneic BK virus-specific T cells may be an effective treatment for patients with progressive multifocal...
From the Journals
Proposed neuroblastoma classification scheme hinges on telomere maintenance mechanisms
Genomic analysis showed telomere maintenance mechanisms, RAS mutations, and p53 mutations were strongly associated with outcome and other disease...
Guidelines
CNS lymphoma guidelines stress patient fitness, not age, in choosing treatment
Patients should be diagnosed fast, treated as aggressively as organ health permits, and in clinical trials if possible.
From the Journals
Bacteremic sepsis in ALL linked to later cognitive issues
Patients who survive acute lymphoblastic leukemia still may face cognitive impairment later in life because of sepsis during treatment.
From the Journals
Immunotherapies extend survival for melanoma patients with brain metastases
Patients with melanoma brain metastases receiving first-line checkpoint blockade immunotherapy had a 91% increase in 4-year survival.
From the Journals
Recombinant poliovirus appears safe, active as recurrent glioblastoma treatment
The survival data in a phase 1 study of 61 patients showed a plateau, with a 36-month survival rate of 21%, compared with 4% for a historical...