Clobetasol Propionate Shampoo 0.05% Is Efficacious and Safe for Long-term Control of Scalp Psoriasis

Clobetasol propionate (CP) shampoo 0.05% is an efficacious and safe treatment for scalp psoriasis. The aim of this double-blind, randomized, placebo-controlled study was to determine if CP shampoo is suitable for long-term disease control. Participants with moderate to severe scalp psoriasis (global severity score [GSS] of 3 or 4 on a scale of 0 [clear] to 5 [very severe]) first received once daily CP shampoo treatment for up to 4 weeks. Responders were subsequently randomized to receive the CP shampoo or vehicle twice weekly maintenance regimen for up to 6 months. When relapse occurred (defined as GSS>2), participants resumed once daily CP shampoo treatment; when symptoms diminished (GSS≤2), they readopted the twice weekly maintenance regimen. At all visits significantly more participants treated with CP shampoo did not relapse compared with participants treated with vehicle (P<.001 only approximately one-third of participants treated with vehicle remained relapse free at month while this rate was observed months later after baseline maintenance phase in the cp shampoo group. group were still versus there no greater incidence skin atrophy telangiectasia or hypothalamic-pituitary-adrenal axis suppression compared clobetasol propionate is efficacious and safe for acute management long-term moderate to severe scalp psoriasis.>