Key clinical point: Current use of hormonal contraceptives was associated with lower mean levels of anti-Müllerian hormone compared to levels in women not on contraceptives; the data may guide clinicians in counseling women to continue their contraceptives during evaluation of ovarian reserve.
Major finding: Compared to women not using any contraceptives, mean anti-Müllerian hormone levels were significantly lower in women using a combined oral contraceptive pill (23.68%), vaginal ring (22.07%), hormonal intrauterine device (6.73%), implant (23.44%), or progestin-only pill (14.80%).
Study details: The data come from a cross-sectional study of 27,125 women aged 20-46 years in the United States. The researchers used dried blood spot cards or venipuncture to assess anti-Müllerian hormone levels.
Disclosures: Modern Fertility, manufacturer of the tests used in the study, paid salaries and consulting fees to the study authors. Lead author Dr. Hariton is a paid consultant for Modern Fertility, has stock options in the company, and his spouse is a Modern Fertility employee.
Source: Hariton E et al. Am J Obstet Gynecol. 2021 Jun 12. doi: 10.1016/j.ajog.2021.06.052.