In all, U.S. adults reported more than 200 different medications associated with depression or suicidal symptoms as adverse effects, said Dr. Qato and co-authors.
The most common, aside from antidepressants, which as a class have a black-box warning for risk of depression, were antihypertensive medications, analgesics, hormonal contraceptives, and proton pump inhibitors. Some are over-the-counter medications that are not labeled indicating depression risk: “Many patients may therefore not be aware of the greater likelihood of concurrent depression associated with these commonly used medications,” Dr. Qato and co-authors wrote.
Dr. Qato reported serving as a consultant for Public Citizen’s Health Research Group, and said she is supported in part by the Robert Wood Johnson Foundation. One co-author reported a grant from Janssen Scientific Affairs, LLC, to Columbia University Medical Center.
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SOURCE: Qato DM, et al. JAMA