The Treatment of Adolescents with Depression Study (TADS) is comparing the efficacy of fluoxetine plus CBT with that of fluoxetine or CBT alone in adolescents with major depression. The study, coordinated by John March, MD, of Duke University Medical Center, is being conducted with 432 teen subjects at 13 clinical sites.
The Treatment of Resistant Depression in Adolescents (TORDIA) study is comparing the efficacy of antidepressant medication plus CBT to that of antidepressants alone in adolescents who have not improved on initial treatment with an SSRI. TORDIA, coordinated by David Brent, MD, University of Pittsburgh, is being conducted at six clinical sites.
NIMH-funded treatment studies in adolescent depression:
Drug brand names
Bupropion • Wellbutrin
Citalopram • Celexa
Fluoxetine • Prozac
Paroxetine • Paxil
Sertraline • Zoloft
Venlafaxine • Effexor
Disclosure
The authors report no affiliation or financial relationship with any of the companies whose products are mentioned in this article. The opinions and assertions contained in this article are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of Health and Human Services or the National Institutes of Health.
