Original Research

Severity Weighting of Postoperative Adverse Events in Orthopedic Surgery

Am J Orthop. 2017 July;46(4):E235-E243

Daniel D. Bohl, MD, MPH

Junyoung Ahn, BS

Adam M. Lukasiewicz, MSc

Andre M. Samuel, BBA

Matthew L. Webb, AB

Bryce A. Basques, MD

Nicholas S. Golinvaux, MD

Kern Singh, MD

Jonathan N. Grauer, MD

Studies of adverse events (AEs) after orthopedic surgery commonly use composite AE outcomes. An example of such an outcome is any AE. These types of outcomes treat AEs with different clinical significance (eg, death, urinary tract infection) similarly. We conducted a study to address this shortcoming in research methodology by creating a single severity-weighted outcome that can be used to characterize the overall severity of a given patient’s postoperative course. All orthopedic faculty members at 2 academic institutions were invited to complete a severity-weighting exercise in which AEs were assigned a percentage severity of death. Mean (standard error) severity weight for urinary tract infection was 0.23% (0.08%); blood transfusion, 0.28% (0.09%); pneumonia, 0.55% (0.15%); hospital readmission, 0.59% (0.23%); wound dehiscence, 0.64% (0.17%); deep vein thrombosis, 0.64% (0.19%); superficial surgical-site infection, 0.68% (0.23%); return to operating room, 0.91% (0.29%); progressive renal insufficiency, 0.93% (0.27%); graft/prosthesis/flap failure, 1.20% (0.34%); unplanned intubation, 1.38% (0.53%); deep surgical-site infection, 1.45% (0.38%); failure to wean from ventilator, 1.45% (0.48%); organ/space surgical-site infection, 1.76% (0.46%); sepsis without shock, 1.77% (0.42%); peripheral nerve injury, 1.83% (0.47%); pulmonary embolism, 2.99% (0.76%); acute renal failure, 3.95% (0.85%); myocardial infarction, 4.16% (0.98%); septic shock, 7.17% (1.36%); stroke, 8.73% (1.74%); cardiac arrest requiring cardiopulmonary resuscitation, 9.97% (2.46%); and coma, 15.14% (3.04%). Future studies may benefit from using this new severity-weighted outcome score.

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References

2. Bohl DD, Russo GS, Basques BA, et al. Variations in data collection methods between national databases affect study results: a comparison of the Nationwide Inpatient Sample and National Surgical Quality Improvement Program databases for lumbar spine fusion procedures. J Bone Joint Surg Am. 2014;96(23):e193.

3. Bohl DD, Grauer JN, Leopold SS. Editor’s spotlight/Take 5: Nationwide Inpatient Sample and National Surgical Quality Improvement Program give different results in hip fracture studies. Clin Orthop Relat Res. 2014;472(6):1667-1671.

4. Levin PE. Apples, oranges, and national databases: commentary on an article by Daniel D. Bohl, MPH, et al.: “Variations in data collection methods between national databases affect study results: a comparison of the Nationwide Inpatient Sample and National Surgical Quality Improvement Program databases for lumbar spine fusion procedures.” J Bone Joint Surg Am. 2014;96(23):e198.

5. Duchman KR, Gao Y, Pugely AJ, Martin CT, Callaghan JJ. Differences in short-term complications between unicompartmental and total knee arthroplasty: a propensity score matched analysis. J Bone Joint Surg Am. 2014;96(16):1387-1394.

6. Edelstein AI, Lovecchio FC, Saha S, Hsu WK, Kim JY. Impact of resident involvement on orthopaedic surgery outcomes: an analysis of 30,628 patients from the American College of Surgeons National Surgical Quality Improvement Program database. J Bone Joint Surg Am. 2014;96(15):e131.

7. Belmont PJ Jr, Goodman GP, Waterman BR, Bader JO, Schoenfeld AJ. Thirty-day postoperative complications and mortality following total knee arthroplasty: incidence and risk factors among a national sample of 15,321 patients. J Bone Joint Surg Am. 2014;96(1):20-26.

8. Martin CT, Pugely AJ, Gao Y, Mendoza-Lattes S. Thirty-day morbidity after single-level anterior cervical discectomy and fusion: identification of risk factors and emphasis on the safety of outpatient procedures. J Bone Joint Surg Am. 2014;96(15):1288-1294.

9. Martin CT, Pugely AJ, Gao Y, Wolf BR. Risk factors for thirty-day morbidity and mortality following knee arthroscopy: a review of 12,271 patients from the National Surgical Quality Improvement Program database. J Bone Joint Surg Am. 2013;95(14):e98 1-10.

10. Pugely AJ, Martin CT, Gao Y, Mendoza-Lattes S, Callaghan JJ. Differences in short-term complications between spinal and general anesthesia for primary total knee arthroplasty. J Bone Joint Surg Am. 2013;95(3):193-199.

11. Odum SM, Springer BD. In-hospital complication rates and associated factors after simultaneous bilateral versus unilateral total knee arthroplasty. J Bone Joint Surg Am. 2014;96(13):1058-1065.

12. Yoshihara H, Yoneoka D. Trends in the incidence and in-hospital outcomes of elective major orthopaedic surgery in patients eighty years of age and older in the United States from 2000 to 2009. J Bone Joint Surg Am. 2014;96(14):1185-1191.

13. Lin CA, Kuo AC, Takemoto S. Comorbidities and perioperative complications in HIV-positive patients undergoing primary total hip and knee arthroplasty. J Bone Joint Surg Am. 2013;95(11):1028-1036.

14. Mednick RE, Alvi HM, Krishnan V, Lovecchio F, Manning DW. Factors affecting readmission rates following primary total hip arthroplasty. J Bone Joint Surg Am. 2014;96(14):1201-1209.

15. Pugely AJ, Martin CT, Gao Y, Ilgenfritz R, Weinstein SL. The incidence and risk factors for short-term morbidity and mortality in pediatric deformity spinal surgery: an analysis of the NSQIP pediatric database. Spine. 2014;39(15):1225-1234.

16. Haughom BD, Schairer WW, Hellman MD, Yi PH, Levine BR. Resident involvement does not influence complication after total hip arthroplasty: an analysis of 13,109 cases. J Arthroplasty. 2014;29(10):1919-1924.

17. Belmont PJ Jr, Goodman GP, Hamilton W, Waterman BR, Bader JO, Schoenfeld AJ. Morbidity and mortality in the thirty-day period following total hip arthroplasty: risk factors and incidence. J Arthroplasty. 2014;29(10):2025-2030.

18. Bohl DD, Fu MC, Golinvaux NS, Basques BA, Gruskay JA, Grauer JN. The “July effect” in primary total hip and knee arthroplasty: analysis of 21,434 cases from the ACS-NSQIP database. J Arthroplasty. 2014;29(7):1332-1338.

19. Bohl DD, Fu MC, Gruskay JA, Basques BA, Golinvaux NS, Grauer JN. “July effect” in elective spine surgery: analysis of the American College of Surgeons National Surgical Quality Improvement Program database. Spine. 2014;39(7):603-611.

20. Babu R, Thomas S, Hazzard MA, et al. Morbidity, mortality, and health care costs for patients undergoing spine surgery following the ACGME resident duty-hour reform: clinical article. J Neurosurg Spine. 2014;21(4):502-515.

21. Lovecchio F, Beal M, Kwasny M, Manning D. Do patients with insulin-dependent and noninsulin-dependent diabetes have different risks for complications after arthroplasty? Clin Orthop Relat Res. 2014;472(11):3570-3575.

22. Pugely AJ, Gao Y, Martin CT, Callagh JJ, Weinstein SL, Marsh JL. The effect of resident participation on short-term outcomes after orthopaedic surgery. Clin Orthop Relat Res. 2014;472(7):2290-2300.

23. Easterlin MC, Chang DG, Talamini M, Chang DC. Older age increases short-term surgical complications after primary knee arthroplasty. Clin Orthop Relat Res. 2013;471(8):2611-2620.

24. Morimoto T, Fukui T. Utilities measured by rating scale, time trade-off, and standard gamble: review and reference for health care professionals. J Epidemiology. 2002;12(2):160-178.

25. Salomon JA, Vos T, Hogan DR, et al. Common values in assessing health outcomes from disease and injury: disability weights measurement study for the Global Burden of Disease Study 2010. Lancet. 2012;380(9859):2129-2143.

26. American College of Surgeons National Surgical Quality Improvement Program. User Guide for the 2011 Participant Use Data File. https://www.facs.org/~/media/files/quality%20programs/nsqip/ug11.ashx. Published October 2012. Accessed December 1, 2013.

27. Molina CS, Thakore RV, Blumer A, Obremskey WT, Sethi MK. Use of the National Surgical Quality Improvement Program in orthopaedic surgery. Clin Orthop Relat Res. 2015;473(5):1574-1581.

28. Strasberg SM, Hall BL. Postoperative Morbidity Index: a quantitative measure of severity of postoperative complications. J Am Coll Surg. 2011;213(5):616-626.

29. Beilan J, Strakosha R, Palacios DA, Rosser CJ. The Postoperative Morbidity Index: a quantitative weighing of postoperative complications applied to urological procedures. BMC Urol. 2014;14:1.

30. Porembka MR, Hall BL, Hirbe M, Strasberg SM. Quantitative weighting of postoperative complications based on the Accordion Severity Grading System: demonstration of potential impact using the American College of Surgeons National Surgical Quality Improvement Program. J Am Coll Surg. 2010;210(3):286-298.

31. Golinvaux NS, Bohl DD, Basques BA, Fu MC, Gardner EC, Grauer JN. Limitations of administrative databases in spine research: a study in obesity. Spine J. 2014;14(12):2923-2928.

32. Golinvaux NS, Bohl DD, Basques BA, Grauer JN. Administrative database concerns: accuracy of International Classification of Diseases, Ninth Revision coding is poor for preoperative anemia in patients undergoing spinal fusion. Spine. 2014;39(24):2019-2023.

33. Bekkers S, Bot AG, Makarawung D, Neuhaus V, Ring D. The National Hospital Discharge Survey and Nationwide Inpatient Sample: the databases used affect results in THA research. Clin Orthop Relat Res. 2014;472(11):3441-3449.

Take-Home Points

Studies of AEs after orthopedic surgery commonly use composite AE outcomes.
These types of outcomes treat AEs with different clinical significance similarly.
This study created a single severity-weighted outcome that can be used to characterize the overall severity of a given patient’s postoperative course.
Future studies may benefit from using this new severity-weighted outcome score.

Recently there has been an increase in the use of national databases for orthopedic surgery research.^1-4 Studies commonly compare rates of postoperative adverse events (AEs) across different demographic, comorbidity, and procedural characteristics.^5-23 Their conclusions often highlight different modifiable and/or nonmodifiable risk factors associated with the occurrence of postoperative events.

The several dozen AEs that have been investigated range from very severe (eg, death, myocardial infarction, coma) to less severe (eg, urinary tract infection [UTI], anemia requiring blood transfusion). A common approach for these studies is to consider many AEs together in the same analysis, asking a question such as, “What are risk factors for the occurrence of ‘adverse events’ after spine surgery?” Such studies test for associations with the occurrence of “any adverse event,” the occurrence of any “serious adverse event,” or similar composite outcomes. How common this type of study has become is indicated by the fact that in 2013 and 2014, at least 12 such studies were published in Clinical Orthopaedics and Related Research and the Journal of Bone and Joint Surgery,^5-14,21-23 and many more in other orthopedic journals.^15-20However, there is a problem in using this type of composite outcome to perform such analyses: AEs with highly varying degrees of severity have identical impacts on the outcome variable, changing it from negative (“no adverse event”) to positive (“at least one adverse event”). As a result, the system may treat a very severe AE such as death and a very minor AE such as UTI similarly. Even in studies that use the slightly more specific composite outcome of “serious adverse events,” death and a nonlethal thromboembolic event would be treated similarly. Failure to differentiate these AEs in terms of their clinical significance detracts from the clinical applicability of conclusions drawn from studies using these types of composite AE outcomes.

In one of many examples that can be considered, a retrospective cohort study compared general and spinal anesthesia used in total knee arthroplasty.¹⁰ The rate of any AEs was higher with general anesthesia than with spinal anesthesia (12.34% vs 10.72%; P = .003). However, the only 2 specific AEs that had statistically significant differences were anemia requiring blood transfusion (6.07% vs 5.02%; P = .009) and superficial surgical-site infection (SSI; 0.92% vs 0.68%; P < .001). These 2 AEs are of relatively low severity; nevertheless, because these AEs are common, their differences constituted the majority of the difference in the rate of any AEs. In contrast, differences in the more severe AEs, such as death (0.11% vs 0.22%; P > .05), septic shock (0.14% vs 0.12%; P > .05), and myocardial infarction (0.20% vs 0.20%; P > .05), were small and not statistically significant. Had more weight been given to these more severe events, the outcome of the study likely would have been “no difference.”

To address this shortcoming in orthopedic research methodology, we created a severity-weighted outcome score that can be used to determine the overall “severity” of any given patient’s postoperative course. We also tested this novel outcome score for correlation with procedure type and patient characteristics using orthopedic patients from the American College of Surgeons (ACS) National Surgical Quality Improvement Program (NSQIP). Our intention is for database investigators to be able to use this outcome score in place of the composite outcomes that are dominating this type of research.

Methods

Generation of Severity Weights

Our method is described generally as utility weighting, assigning value weights reflective of overall impact to differing outcome states.²⁴ Parallel methods have been used to generate the disability weights used to determine disability-adjusted life years for the Global Burden of Disease project²⁵ and many other areas of health, economic, and policy research.

All orthopedic faculty members at 2 geographically disparate, large US academic institutions were invited to participate in a severity-weighting exercise. Each surgeon who agreed to participate performed the exercise independently.

Each participant was given a stack of 23 index cards, each listing the name and description of an AE monitored by ACS-NSQIP (Table 1).²⁶ In addition, in the upper right corner of each card was a box in which the participant could write a number. Each stack of cards was provided in a distinct randomized order. Written instructions for participants were exactly as follows:

STEP 1: Please reorder the AE cards by your perception of “severity” for a patient experiencing that event after an orthopedic procedure.
STEP 2: Once your cards are in order, please determine how many postoperative occurrences of each event you would “trade” for 1 patient experiencing postoperative death. Place this number of occurrences in the box in the upper right corner of each card.
NOTES: As you consider each AE:
Please consider an “average” occurrence of that AE, but note that in no case does the AE result in perioperative death.
Please consider only the “severity” for the patient. (Do not consider the extent to which the event may be related to surgical error.)
Please consider that the numbers you assign are relative to each other. Hence, if you would trade 20 of “event A” for 1 death, and if you would trade 40 of “event B” for 1 death, the implication is that you would trade 20 of “event A” for 40 of “event B.”
You may readjust the order of your cards at any point.

Participants’ responses were recorded. For each number provided by each participant, the inverse (reciprocal) was taken and multiplied by 100%. This new number was taken to be the percentage severity of death that the given participant considered the given AE to embody. For example, as a hypothetical on one end of the spectrum, if a participant reported 1 (he/she would trade 1 AE X for 1 death), then the severity would be 1/1 × 100% = 100% of death, a very severe AE. Conversely, if a participant reported a very large number like 100,000 (he/she would trade 100,000 AEs X for 1 death), then the severity would be 1/100,000 × 100% = 0.001% of death, a very minor AE. More commonly, a participant will report a number like 25, which would translate to 4% of death (1/25 × 100% = 4%). For each AE, weights were then averaged across participants to derive a mean severity weight to be used to generate a novel composite outcome score.

Definition of Novel Composite Outcome Score

The novel composite outcome score would be expressed as a percentage to be interpreted as percentage severity of death, which we termed severity-weighted outcome relative to death (SWORD). For each patient, SWORD was defined as no AE (0%) or postoperative death (100%), with other AEs assigned mean severity weights based on faculty members’ survey responses. A patient with multiple AEs would be assigned the weight for the more severe AE. This method was chosen over summing the AE weights because in many cases the AEs were thought to overlap; hence, summing would be inappropriate. For example, generally a deep SSI would result in a return to the operating room, and one would not want to double-count this AE. Similarly, it would not make sense for a patient who died of a complication to have a SWORD of >100%, which would be the summing result.

Application to ACS-NSQIP Patients

ACS-NSQIP is a surgical registry that prospectively identifies patients undergoing major surgery at any of >500 institutions nationwide.^26,27 Patients are characterized at baseline and are followed for AEs over the first 30 postoperative days.

Patients undergoing any of 8 common orthopedic procedures were identified in the 2012 ACS-NSQIP database using International Classification of Diseases, Ninth Revision (ICD-9) codes and Current Procedural Terminology (CPT) codes (Table 2). Any patient with missing data was excluded from this population before analysis.

First, mean SWORD was calculated and reported for patients undergoing each of the 8 procedures. Analysis of variance (ANOVA) was used to test for associations of mean SWORD with type of procedure both before and after multivariate adjustment for demographics (sex; age in years, <40, 40-49, 50-59, 60-69, 70-79, 80-89, ≥90) and comorbidities (diabetes, hypertension, chronic obstructive pulmonary disease, exertional dyspnea, end-stage renal disease, congestive heart failure).

Second, patients undergoing the procedure with the highest mean SWORD (hip fracture surgery) were examined in depth. Among only these patients, multivariate ANOVA was used to test for associations of mean SWORD with the same demographics and comorbidities.

All statistical tests were 2-tailed. Significance was set at α = 0.05 (P < .05).

All 23 institution A faculty members (100%) and 24 (89%) of the 27 institution B faculty members completed the exercise.

Total number of participants was 47, and the overall response rate was 94%. Participant characteristics are listed in Table 3.

In the ACS-NSQIP database, 85,109 patients were identified on the basis of the initial inclusion criteria.

After patients with missing data were excluded, 85,031 remained for analysis. Patient characteristics are listed in Table 4.

References

1. Bohl DD, Basques BA, Golinvaux NS, Baumgaertner MR, Grauer JN. Nationwide Inpatient Sample and National Surgical Quality Improvement Program give different results in hip fracture studies. Clin Orthop Relat Res. 2014;472(6):1672-1680.

2. Bohl DD, Russo GS, Basques BA, et al. Variations in data collection methods between national databases affect study results: a comparison of the Nationwide Inpatient Sample and National Surgical Quality Improvement Program databases for lumbar spine fusion procedures. J Bone Joint Surg Am. 2014;96(23):e193.

3. Bohl DD, Grauer JN, Leopold SS. Editor’s spotlight/Take 5: Nationwide Inpatient Sample and National Surgical Quality Improvement Program give different results in hip fracture studies. Clin Orthop Relat Res. 2014;472(6):1667-1671.

4. Levin PE. Apples, oranges, and national databases: commentary on an article by Daniel D. Bohl, MPH, et al.: “Variations in data collection methods between national databases affect study results: a comparison of the Nationwide Inpatient Sample and National Surgical Quality Improvement Program databases for lumbar spine fusion procedures.” J Bone Joint Surg Am. 2014;96(23):e198.

5. Duchman KR, Gao Y, Pugely AJ, Martin CT, Callaghan JJ. Differences in short-term complications between unicompartmental and total knee arthroplasty: a propensity score matched analysis. J Bone Joint Surg Am. 2014;96(16):1387-1394.

6. Edelstein AI, Lovecchio FC, Saha S, Hsu WK, Kim JY. Impact of resident involvement on orthopaedic surgery outcomes: an analysis of 30,628 patients from the American College of Surgeons National Surgical Quality Improvement Program database. J Bone Joint Surg Am. 2014;96(15):e131.

7. Belmont PJ Jr, Goodman GP, Waterman BR, Bader JO, Schoenfeld AJ. Thirty-day postoperative complications and mortality following total knee arthroplasty: incidence and risk factors among a national sample of 15,321 patients. J Bone Joint Surg Am. 2014;96(1):20-26.

8. Martin CT, Pugely AJ, Gao Y, Mendoza-Lattes S. Thirty-day morbidity after single-level anterior cervical discectomy and fusion: identification of risk factors and emphasis on the safety of outpatient procedures. J Bone Joint Surg Am. 2014;96(15):1288-1294.

9. Martin CT, Pugely AJ, Gao Y, Wolf BR. Risk factors for thirty-day morbidity and mortality following knee arthroscopy: a review of 12,271 patients from the National Surgical Quality Improvement Program database. J Bone Joint Surg Am. 2013;95(14):e98 1-10.

10. Pugely AJ, Martin CT, Gao Y, Mendoza-Lattes S, Callaghan JJ. Differences in short-term complications between spinal and general anesthesia for primary total knee arthroplasty. J Bone Joint Surg Am. 2013;95(3):193-199.

11. Odum SM, Springer BD. In-hospital complication rates and associated factors after simultaneous bilateral versus unilateral total knee arthroplasty. J Bone Joint Surg Am. 2014;96(13):1058-1065.

12. Yoshihara H, Yoneoka D. Trends in the incidence and in-hospital outcomes of elective major orthopaedic surgery in patients eighty years of age and older in the United States from 2000 to 2009. J Bone Joint Surg Am. 2014;96(14):1185-1191.

13. Lin CA, Kuo AC, Takemoto S. Comorbidities and perioperative complications in HIV-positive patients undergoing primary total hip and knee arthroplasty. J Bone Joint Surg Am. 2013;95(11):1028-1036.

14. Mednick RE, Alvi HM, Krishnan V, Lovecchio F, Manning DW. Factors affecting readmission rates following primary total hip arthroplasty. J Bone Joint Surg Am. 2014;96(14):1201-1209.

15. Pugely AJ, Martin CT, Gao Y, Ilgenfritz R, Weinstein SL. The incidence and risk factors for short-term morbidity and mortality in pediatric deformity spinal surgery: an analysis of the NSQIP pediatric database. Spine. 2014;39(15):1225-1234.

16. Haughom BD, Schairer WW, Hellman MD, Yi PH, Levine BR. Resident involvement does not influence complication after total hip arthroplasty: an analysis of 13,109 cases. J Arthroplasty. 2014;29(10):1919-1924.

17. Belmont PJ Jr, Goodman GP, Hamilton W, Waterman BR, Bader JO, Schoenfeld AJ. Morbidity and mortality in the thirty-day period following total hip arthroplasty: risk factors and incidence. J Arthroplasty. 2014;29(10):2025-2030.

18. Bohl DD, Fu MC, Golinvaux NS, Basques BA, Gruskay JA, Grauer JN. The “July effect” in primary total hip and knee arthroplasty: analysis of 21,434 cases from the ACS-NSQIP database. J Arthroplasty. 2014;29(7):1332-1338.

19. Bohl DD, Fu MC, Gruskay JA, Basques BA, Golinvaux NS, Grauer JN. “July effect” in elective spine surgery: analysis of the American College of Surgeons National Surgical Quality Improvement Program database. Spine. 2014;39(7):603-611.

20. Babu R, Thomas S, Hazzard MA, et al. Morbidity, mortality, and health care costs for patients undergoing spine surgery following the ACGME resident duty-hour reform: clinical article. J Neurosurg Spine. 2014;21(4):502-515.

21. Lovecchio F, Beal M, Kwasny M, Manning D. Do patients with insulin-dependent and noninsulin-dependent diabetes have different risks for complications after arthroplasty? Clin Orthop Relat Res. 2014;472(11):3570-3575.

22. Pugely AJ, Gao Y, Martin CT, Callagh JJ, Weinstein SL, Marsh JL. The effect of resident participation on short-term outcomes after orthopaedic surgery. Clin Orthop Relat Res. 2014;472(7):2290-2300.

23. Easterlin MC, Chang DG, Talamini M, Chang DC. Older age increases short-term surgical complications after primary knee arthroplasty. Clin Orthop Relat Res. 2013;471(8):2611-2620.

24. Morimoto T, Fukui T. Utilities measured by rating scale, time trade-off, and standard gamble: review and reference for health care professionals. J Epidemiology. 2002;12(2):160-178.

25. Salomon JA, Vos T, Hogan DR, et al. Common values in assessing health outcomes from disease and injury: disability weights measurement study for the Global Burden of Disease Study 2010. Lancet. 2012;380(9859):2129-2143.

26. American College of Surgeons National Surgical Quality Improvement Program. User Guide for the 2011 Participant Use Data File. https://www.facs.org/~/media/files/quality%20programs/nsqip/ug11.ashx. Published October 2012. Accessed December 1, 2013.

27. Molina CS, Thakore RV, Blumer A, Obremskey WT, Sethi MK. Use of the National Surgical Quality Improvement Program in orthopaedic surgery. Clin Orthop Relat Res. 2015;473(5):1574-1581.

28. Strasberg SM, Hall BL. Postoperative Morbidity Index: a quantitative measure of severity of postoperative complications. J Am Coll Surg. 2011;213(5):616-626.

29. Beilan J, Strakosha R, Palacios DA, Rosser CJ. The Postoperative Morbidity Index: a quantitative weighing of postoperative complications applied to urological procedures. BMC Urol. 2014;14:1.

30. Porembka MR, Hall BL, Hirbe M, Strasberg SM. Quantitative weighting of postoperative complications based on the Accordion Severity Grading System: demonstration of potential impact using the American College of Surgeons National Surgical Quality Improvement Program. J Am Coll Surg. 2010;210(3):286-298.

31. Golinvaux NS, Bohl DD, Basques BA, Fu MC, Gardner EC, Grauer JN. Limitations of administrative databases in spine research: a study in obesity. Spine J. 2014;14(12):2923-2928.

32. Golinvaux NS, Bohl DD, Basques BA, Grauer JN. Administrative database concerns: accuracy of International Classification of Diseases, Ninth Revision coding is poor for preoperative anemia in patients undergoing spinal fusion. Spine. 2014;39(24):2019-2023.

Severity Weighting of Postoperative Adverse Events in Orthopedic Surgery

References

Take-Home Points

Methods

Generation of Severity Weights

Definition of Novel Composite Outcome Score

Application to ACS-NSQIP Patients

Pages

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