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Annular Atrophic Lichen Planus Responds to Hydroxychloroquine and Acitretin

Annular atrophic lichen planus (AALP) is a rare variant of lichen planus that was first described by Friedman and Hashimoto1 in 1991. Clinically, it combines the configuration and morphological features of both annular and atrophic lichen planus. It is a rare entity. We report a case of AALP in a 69-year-old black man. The clinical and histopathological presentation depicted the defining features of this entity with a characteristic loss of elastic fibers corresponding to central atrophy of active lesions.

Case Report

A 69-year-old black man with a history of hepatitis C virus infection and hypothyroidism presented to the dermatology clinic with a pruritic rash on the trunk, extremities, groin, and scalp of 4 months' duration. He denied any new medications, recent illnesses, or sick contacts. Physical examination demonstrated well-demarcated violaceous papules and plaques on the trunk, extensor aspect of the forearms, and thighs involving 10% of the body surface area (Figure 1A). The lesions were annular with raised borders and central depigmented atrophic scarring (Figure 1B). The examination also revealed several large hypopigmented atrophic patches and plaques in the right inguinal region and on the dorsal aspect of the penile shaft and buttocks as well as a single atrophic plaque on the scalp. No oral lesions were seen. An initial punch biopsy was consistent with a nonspecific lichenoid dermatitis (Figure 2), and the patient was prescribed triamcinolone ointment 0.1% for the trunk and extremities and tacrolimus ointment 0.1% for the groin and genital region.

Figure 1. Annular atrophic lichen planus with well-demarcated, hyperpigmented, violaceous annular plaques on the left posterior thigh (A) and posterior trunk (B) with elevated borders and central depigmented atrophic scarring.

Figure 2. Punch biopsy from the left posterior thigh showed compact hyperkeratosis, hypergranulosis, Civatte bodies, and focal acanthosis with an underlying lichenoid dermatitis composed of a lymphohistiocytic infiltrate partially obscuring the dermoepidermal junction (H&E, original magnification ×40).

The patient continued to develop new annular atrophic skin lesions over the next several months. Repeat punch biopsies of lesional and uninvolved perilesional skin from the trunk were obtained for histopathologic confirmation and special staining. Lichenoid dermatitis again was noted on the lesional biopsy, and no notable histopathologic changes were observed on the perilesional biopsy. Verhoeff-van Gieson staining for elastic fibers was performed on both biopsies, which revealed destruction of elastic fibers in the central papillary dermis and upper reticular dermis of the lesional biopsy (Figure 3A). The elastic fibers on the perilesional biopsy were preserved (Figure 3B).

Figure 3. Verhoeff-van Gieson staining performed on a punch biopsy of a lesion from the upper back showed a decreased amount of elastic fibers in the dermis (A)(original magnification ×200). Punch biopsy of clinically unaffected adjacent skin was unremarkable with preservation of elastic fibers (B)(original magnification ×200).

The clinical presentation and histopathological findings confirmed a diagnosis of AALP. The patient was prescribed a short taper of oral prednisone, which halted further disease progression. The patient was then started on pentoxifylline and continued on tacrolimus ointment 0.1% with minimal improvement in existing lesions. These medications were discontinued after 3 months. Hydroxychloroquine 400 mg once daily was administered, which initially resulted in some thinning of the plaques on the trunk; however, further progression of the disease was noted after 3 months. Acitretin 25 mg once daily was added to his treatment regimen. Marked thinning of active lesions, hyperpigmentation, and residual scarring was noted after 2 months of combined therapy with acitretin and hydroxychloroquine (Figure 4), with continued improvement appreciable several months later.

Figure 4. Annular atrophic lichen planus with lesional thinning, hyperpigmentation, and residual scarring after 2 months of combined treatment with hydroxychloroquine 400 mg and acitretin 25 mg both once daily.

 

 

Comment

Lichen planus is a common pruritic inflammatory disease of the skin, mucous membranes, hair follicles, and nails with a highly variable clinical pattern and disease course that typically affects the adult population.2 There are many clinical variants of lichen planus, which all demonstrate lichenoid dermatitis on histology. Annular lichen planus is an uncommon variant most commonly seen in men with asymptomatic lesions involving the axillae and groin.2 Atrophic lichen planus is another variant demonstrating atrophic papules and plaques on the trunk and extremities.3 Annular atrophic lichen planus is the rarest variant of lichen planus, incorporating features of both annular and atrophic lichen planus.

The first case of AALP involved a 56-year-old black man with a 25-year history of annular atrophic papules and plaques on the trunk and extremities.1 The second case reported by Requena et al4 in 1994 described a 65-year-old woman with characteristic lesions on the right elbow and left knee. Lipsker et al5 reported a third case in a 41-year-old man with a history of Sneddon syndrome who had lesions typical for AALP for 20 years. In all of these cases, histopathologic examination revealed a lichenoid infiltrate with thinning of the epidermis and loss of elastic fibers in the center of the active lesions.

In more recent cases of AALP, the characteristic findings primarily occurred on the trunk and extremities.6-10 Treatment with topical corticosteroids failed in most cases and some patients noted moderate improvement with tacrolimus ointment 0.1%. Sugashima and Yamamoto11 reported a unique case in 2012 of a 32-year-old woman with AALP on the lower lip. She had notable improvement with tacrolimus ointment 0.1% after 6 months.11

All of the known cases of AALP to date have occurred in adults, both male and female, presenting with a limited number of annular plaques with slightly elevated borders and depressed atrophic centers.1,3-11 Disease duration of AALP has ranged from 2 months to 25 years.11 Histopathologic findings characteristically demonstrate a lichenoid dermatitis of the raised lesional border with a flattened epidermis, loss of rete ridges, and fibrosis of dermal papillae in the lesion center.7 The elastic fibers are destroyed in the papillary dermis of the lesion center, presumably due to elastolytic activity of inflammatory cells.1 Macrophages present in the lichenoid infiltrate of acute lesions release elastases contributing to this destruction.7 Furthermore, elastic fibers appear fragmented on electron microscopy.1

The clinical course of AALP has proven to be chronic in most cases and frequently is resistant to treatment with topical corticosteroids, retinoids, phototherapy, and immunosuppressive agents.3 Treatment administered early in the disease course may provide a more favorable outcome.11 Lesions characteristically heal with scarring and hyperpigmentation. Our case displayed more extensive involvement than has previously been reported. Our patient showed minimal improvement with topical therapy; however, he demonstrated thinning and regression of active lesions after 2 months of combined treatment with hydroxychloroquine and acitretin. Our use of oral pentoxifylline, hydroxychloroquine, and acitretin has not been previously reported in the other cases of AALP we reviewed. Acitretin is the only systemic agent for lichen planus that has achieved level A evidence, as it previously was shown to be highly effective in a placebo-controlled, double-blind study of 65 patients.12

Conclusion

Annular atrophic lichen planus is a known variant of lichen planus characterized by a loss of elastic fibers in the papillary dermis in the center of active lesions. Treatment with topical corticosteroids and phototherapy frequently is ineffective. To our knowledge, there are no studies to date regarding the efficacy of systemic therapy in treatment of AALP. Hydroxychloroquine and acitretin may prove to be beneficial treatment options for resistant AALP. Additional alternative treatments continue to be explored. We encourage reporting additional cases of AALP to further characterize its clinical presentation and response to treatments.

References
  1. Friedman DB, Hashimoto K. Annular atrophic lichen planus. J Am Acad Dermatol. 1991;25:392-394.
  2. James WD, Berger TG, Elston DM. Lichen planus and related conditions. In: James WD, Berger TG, Elston DM, eds. Andrews' Diseases of the Skin: Clinical Dermatology. 11th ed. China: Saunders Elsevier; 2011:213-215.  
  3. Kim BS, Seo SH, Jang BS, et al. A case of annular atrophic lichen planus. J Eur Acad Dermatol Venereol. 2007;21:989-990.
  4. Requena L, Olivares M, Pique E, et al. Annular atrophic lichen planus. Dermatology. 1994;189:95-98.
  5. Lipsker D, Piette JC, Laporte JL, et al. Annular atrophic lichen planus and Sneddon's syndrome. Dermatology. 1997;105:402-403.
  6. Mseddi M, Bouassadi S, Marrakchi S, et al. Annular atrophic lichen planus. Dermatology. 2003;207:208-209.
  7. Morales-Callaghan A Jr, Martinez G, Aragoneses H, et al. Annular atrophic lichen planus. J Am Acad Dermatol. 2005;52:906-908.
  8. Ponce-Olivera RM, Tirado-Sánchez A, Montes-de-Oca-Sánchez G, et al. Annular atrophic lichen planus. Int J Dermatol. 2007;46:490-491.
  9. Kim JS, Kang MS, Sagong C, et al. Annular atrophic lichen planus associated with hypertrophic lichen planus. Clin Exp Dermatol. 2008;33:195-197.
  10. Li B, Li JH, Xiao T, et al. Annular atrophic lichen planus. Eur J Dermatol. 2010;20:842-843.
  11. Sugashima Y, Yamamoto T. Annular atrophic lichen planus of the lip. Dermatol Online J. 2012;18:14.
  12. Manousaridis I, Manousaridis K, Peitsch WK, et al. Individualizing treatment and choice of medication in lichen planus: a step by step approach. J Dtsch Dermatol Ges. 2013;11:981-991.
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Drs. Eyler, Garib, and Swan are from Loyola University Medical Center, Maywood, Illinois. Drs. Eyler and Swan are from the Division of Dermatology, and Dr. Garib is from the Department of Pathology. Ms. Thompson is from Pritzker School of Medicine, The University of Chicago, Illinois. Dr. Dahiya is from the Department of Pathology, Edward Hines Jr. VA Hospital, Hines, Illinois.

The authors report no conflict of interest.

Correspondence: Jennifer T. Eyler, MD, Loyola University Medical Center, Division of Dermatology, Bldg 54, Room 101, Maywood, IL 60153 (jenthompson11@gmail.com).

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Drs. Eyler, Garib, and Swan are from Loyola University Medical Center, Maywood, Illinois. Drs. Eyler and Swan are from the Division of Dermatology, and Dr. Garib is from the Department of Pathology. Ms. Thompson is from Pritzker School of Medicine, The University of Chicago, Illinois. Dr. Dahiya is from the Department of Pathology, Edward Hines Jr. VA Hospital, Hines, Illinois.

The authors report no conflict of interest.

Correspondence: Jennifer T. Eyler, MD, Loyola University Medical Center, Division of Dermatology, Bldg 54, Room 101, Maywood, IL 60153 (jenthompson11@gmail.com).

Author and Disclosure Information

Drs. Eyler, Garib, and Swan are from Loyola University Medical Center, Maywood, Illinois. Drs. Eyler and Swan are from the Division of Dermatology, and Dr. Garib is from the Department of Pathology. Ms. Thompson is from Pritzker School of Medicine, The University of Chicago, Illinois. Dr. Dahiya is from the Department of Pathology, Edward Hines Jr. VA Hospital, Hines, Illinois.

The authors report no conflict of interest.

Correspondence: Jennifer T. Eyler, MD, Loyola University Medical Center, Division of Dermatology, Bldg 54, Room 101, Maywood, IL 60153 (jenthompson11@gmail.com).

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Related Articles

Annular atrophic lichen planus (AALP) is a rare variant of lichen planus that was first described by Friedman and Hashimoto1 in 1991. Clinically, it combines the configuration and morphological features of both annular and atrophic lichen planus. It is a rare entity. We report a case of AALP in a 69-year-old black man. The clinical and histopathological presentation depicted the defining features of this entity with a characteristic loss of elastic fibers corresponding to central atrophy of active lesions.

Case Report

A 69-year-old black man with a history of hepatitis C virus infection and hypothyroidism presented to the dermatology clinic with a pruritic rash on the trunk, extremities, groin, and scalp of 4 months' duration. He denied any new medications, recent illnesses, or sick contacts. Physical examination demonstrated well-demarcated violaceous papules and plaques on the trunk, extensor aspect of the forearms, and thighs involving 10% of the body surface area (Figure 1A). The lesions were annular with raised borders and central depigmented atrophic scarring (Figure 1B). The examination also revealed several large hypopigmented atrophic patches and plaques in the right inguinal region and on the dorsal aspect of the penile shaft and buttocks as well as a single atrophic plaque on the scalp. No oral lesions were seen. An initial punch biopsy was consistent with a nonspecific lichenoid dermatitis (Figure 2), and the patient was prescribed triamcinolone ointment 0.1% for the trunk and extremities and tacrolimus ointment 0.1% for the groin and genital region.

Figure 1. Annular atrophic lichen planus with well-demarcated, hyperpigmented, violaceous annular plaques on the left posterior thigh (A) and posterior trunk (B) with elevated borders and central depigmented atrophic scarring.

Figure 2. Punch biopsy from the left posterior thigh showed compact hyperkeratosis, hypergranulosis, Civatte bodies, and focal acanthosis with an underlying lichenoid dermatitis composed of a lymphohistiocytic infiltrate partially obscuring the dermoepidermal junction (H&E, original magnification ×40).

The patient continued to develop new annular atrophic skin lesions over the next several months. Repeat punch biopsies of lesional and uninvolved perilesional skin from the trunk were obtained for histopathologic confirmation and special staining. Lichenoid dermatitis again was noted on the lesional biopsy, and no notable histopathologic changes were observed on the perilesional biopsy. Verhoeff-van Gieson staining for elastic fibers was performed on both biopsies, which revealed destruction of elastic fibers in the central papillary dermis and upper reticular dermis of the lesional biopsy (Figure 3A). The elastic fibers on the perilesional biopsy were preserved (Figure 3B).

Figure 3. Verhoeff-van Gieson staining performed on a punch biopsy of a lesion from the upper back showed a decreased amount of elastic fibers in the dermis (A)(original magnification ×200). Punch biopsy of clinically unaffected adjacent skin was unremarkable with preservation of elastic fibers (B)(original magnification ×200).

The clinical presentation and histopathological findings confirmed a diagnosis of AALP. The patient was prescribed a short taper of oral prednisone, which halted further disease progression. The patient was then started on pentoxifylline and continued on tacrolimus ointment 0.1% with minimal improvement in existing lesions. These medications were discontinued after 3 months. Hydroxychloroquine 400 mg once daily was administered, which initially resulted in some thinning of the plaques on the trunk; however, further progression of the disease was noted after 3 months. Acitretin 25 mg once daily was added to his treatment regimen. Marked thinning of active lesions, hyperpigmentation, and residual scarring was noted after 2 months of combined therapy with acitretin and hydroxychloroquine (Figure 4), with continued improvement appreciable several months later.

Figure 4. Annular atrophic lichen planus with lesional thinning, hyperpigmentation, and residual scarring after 2 months of combined treatment with hydroxychloroquine 400 mg and acitretin 25 mg both once daily.

 

 

Comment

Lichen planus is a common pruritic inflammatory disease of the skin, mucous membranes, hair follicles, and nails with a highly variable clinical pattern and disease course that typically affects the adult population.2 There are many clinical variants of lichen planus, which all demonstrate lichenoid dermatitis on histology. Annular lichen planus is an uncommon variant most commonly seen in men with asymptomatic lesions involving the axillae and groin.2 Atrophic lichen planus is another variant demonstrating atrophic papules and plaques on the trunk and extremities.3 Annular atrophic lichen planus is the rarest variant of lichen planus, incorporating features of both annular and atrophic lichen planus.

The first case of AALP involved a 56-year-old black man with a 25-year history of annular atrophic papules and plaques on the trunk and extremities.1 The second case reported by Requena et al4 in 1994 described a 65-year-old woman with characteristic lesions on the right elbow and left knee. Lipsker et al5 reported a third case in a 41-year-old man with a history of Sneddon syndrome who had lesions typical for AALP for 20 years. In all of these cases, histopathologic examination revealed a lichenoid infiltrate with thinning of the epidermis and loss of elastic fibers in the center of the active lesions.

In more recent cases of AALP, the characteristic findings primarily occurred on the trunk and extremities.6-10 Treatment with topical corticosteroids failed in most cases and some patients noted moderate improvement with tacrolimus ointment 0.1%. Sugashima and Yamamoto11 reported a unique case in 2012 of a 32-year-old woman with AALP on the lower lip. She had notable improvement with tacrolimus ointment 0.1% after 6 months.11

All of the known cases of AALP to date have occurred in adults, both male and female, presenting with a limited number of annular plaques with slightly elevated borders and depressed atrophic centers.1,3-11 Disease duration of AALP has ranged from 2 months to 25 years.11 Histopathologic findings characteristically demonstrate a lichenoid dermatitis of the raised lesional border with a flattened epidermis, loss of rete ridges, and fibrosis of dermal papillae in the lesion center.7 The elastic fibers are destroyed in the papillary dermis of the lesion center, presumably due to elastolytic activity of inflammatory cells.1 Macrophages present in the lichenoid infiltrate of acute lesions release elastases contributing to this destruction.7 Furthermore, elastic fibers appear fragmented on electron microscopy.1

The clinical course of AALP has proven to be chronic in most cases and frequently is resistant to treatment with topical corticosteroids, retinoids, phototherapy, and immunosuppressive agents.3 Treatment administered early in the disease course may provide a more favorable outcome.11 Lesions characteristically heal with scarring and hyperpigmentation. Our case displayed more extensive involvement than has previously been reported. Our patient showed minimal improvement with topical therapy; however, he demonstrated thinning and regression of active lesions after 2 months of combined treatment with hydroxychloroquine and acitretin. Our use of oral pentoxifylline, hydroxychloroquine, and acitretin has not been previously reported in the other cases of AALP we reviewed. Acitretin is the only systemic agent for lichen planus that has achieved level A evidence, as it previously was shown to be highly effective in a placebo-controlled, double-blind study of 65 patients.12

Conclusion

Annular atrophic lichen planus is a known variant of lichen planus characterized by a loss of elastic fibers in the papillary dermis in the center of active lesions. Treatment with topical corticosteroids and phototherapy frequently is ineffective. To our knowledge, there are no studies to date regarding the efficacy of systemic therapy in treatment of AALP. Hydroxychloroquine and acitretin may prove to be beneficial treatment options for resistant AALP. Additional alternative treatments continue to be explored. We encourage reporting additional cases of AALP to further characterize its clinical presentation and response to treatments.

Annular atrophic lichen planus (AALP) is a rare variant of lichen planus that was first described by Friedman and Hashimoto1 in 1991. Clinically, it combines the configuration and morphological features of both annular and atrophic lichen planus. It is a rare entity. We report a case of AALP in a 69-year-old black man. The clinical and histopathological presentation depicted the defining features of this entity with a characteristic loss of elastic fibers corresponding to central atrophy of active lesions.

Case Report

A 69-year-old black man with a history of hepatitis C virus infection and hypothyroidism presented to the dermatology clinic with a pruritic rash on the trunk, extremities, groin, and scalp of 4 months' duration. He denied any new medications, recent illnesses, or sick contacts. Physical examination demonstrated well-demarcated violaceous papules and plaques on the trunk, extensor aspect of the forearms, and thighs involving 10% of the body surface area (Figure 1A). The lesions were annular with raised borders and central depigmented atrophic scarring (Figure 1B). The examination also revealed several large hypopigmented atrophic patches and plaques in the right inguinal region and on the dorsal aspect of the penile shaft and buttocks as well as a single atrophic plaque on the scalp. No oral lesions were seen. An initial punch biopsy was consistent with a nonspecific lichenoid dermatitis (Figure 2), and the patient was prescribed triamcinolone ointment 0.1% for the trunk and extremities and tacrolimus ointment 0.1% for the groin and genital region.

Figure 1. Annular atrophic lichen planus with well-demarcated, hyperpigmented, violaceous annular plaques on the left posterior thigh (A) and posterior trunk (B) with elevated borders and central depigmented atrophic scarring.

Figure 2. Punch biopsy from the left posterior thigh showed compact hyperkeratosis, hypergranulosis, Civatte bodies, and focal acanthosis with an underlying lichenoid dermatitis composed of a lymphohistiocytic infiltrate partially obscuring the dermoepidermal junction (H&E, original magnification ×40).

The patient continued to develop new annular atrophic skin lesions over the next several months. Repeat punch biopsies of lesional and uninvolved perilesional skin from the trunk were obtained for histopathologic confirmation and special staining. Lichenoid dermatitis again was noted on the lesional biopsy, and no notable histopathologic changes were observed on the perilesional biopsy. Verhoeff-van Gieson staining for elastic fibers was performed on both biopsies, which revealed destruction of elastic fibers in the central papillary dermis and upper reticular dermis of the lesional biopsy (Figure 3A). The elastic fibers on the perilesional biopsy were preserved (Figure 3B).

Figure 3. Verhoeff-van Gieson staining performed on a punch biopsy of a lesion from the upper back showed a decreased amount of elastic fibers in the dermis (A)(original magnification ×200). Punch biopsy of clinically unaffected adjacent skin was unremarkable with preservation of elastic fibers (B)(original magnification ×200).

The clinical presentation and histopathological findings confirmed a diagnosis of AALP. The patient was prescribed a short taper of oral prednisone, which halted further disease progression. The patient was then started on pentoxifylline and continued on tacrolimus ointment 0.1% with minimal improvement in existing lesions. These medications were discontinued after 3 months. Hydroxychloroquine 400 mg once daily was administered, which initially resulted in some thinning of the plaques on the trunk; however, further progression of the disease was noted after 3 months. Acitretin 25 mg once daily was added to his treatment regimen. Marked thinning of active lesions, hyperpigmentation, and residual scarring was noted after 2 months of combined therapy with acitretin and hydroxychloroquine (Figure 4), with continued improvement appreciable several months later.

Figure 4. Annular atrophic lichen planus with lesional thinning, hyperpigmentation, and residual scarring after 2 months of combined treatment with hydroxychloroquine 400 mg and acitretin 25 mg both once daily.

 

 

Comment

Lichen planus is a common pruritic inflammatory disease of the skin, mucous membranes, hair follicles, and nails with a highly variable clinical pattern and disease course that typically affects the adult population.2 There are many clinical variants of lichen planus, which all demonstrate lichenoid dermatitis on histology. Annular lichen planus is an uncommon variant most commonly seen in men with asymptomatic lesions involving the axillae and groin.2 Atrophic lichen planus is another variant demonstrating atrophic papules and plaques on the trunk and extremities.3 Annular atrophic lichen planus is the rarest variant of lichen planus, incorporating features of both annular and atrophic lichen planus.

The first case of AALP involved a 56-year-old black man with a 25-year history of annular atrophic papules and plaques on the trunk and extremities.1 The second case reported by Requena et al4 in 1994 described a 65-year-old woman with characteristic lesions on the right elbow and left knee. Lipsker et al5 reported a third case in a 41-year-old man with a history of Sneddon syndrome who had lesions typical for AALP for 20 years. In all of these cases, histopathologic examination revealed a lichenoid infiltrate with thinning of the epidermis and loss of elastic fibers in the center of the active lesions.

In more recent cases of AALP, the characteristic findings primarily occurred on the trunk and extremities.6-10 Treatment with topical corticosteroids failed in most cases and some patients noted moderate improvement with tacrolimus ointment 0.1%. Sugashima and Yamamoto11 reported a unique case in 2012 of a 32-year-old woman with AALP on the lower lip. She had notable improvement with tacrolimus ointment 0.1% after 6 months.11

All of the known cases of AALP to date have occurred in adults, both male and female, presenting with a limited number of annular plaques with slightly elevated borders and depressed atrophic centers.1,3-11 Disease duration of AALP has ranged from 2 months to 25 years.11 Histopathologic findings characteristically demonstrate a lichenoid dermatitis of the raised lesional border with a flattened epidermis, loss of rete ridges, and fibrosis of dermal papillae in the lesion center.7 The elastic fibers are destroyed in the papillary dermis of the lesion center, presumably due to elastolytic activity of inflammatory cells.1 Macrophages present in the lichenoid infiltrate of acute lesions release elastases contributing to this destruction.7 Furthermore, elastic fibers appear fragmented on electron microscopy.1

The clinical course of AALP has proven to be chronic in most cases and frequently is resistant to treatment with topical corticosteroids, retinoids, phototherapy, and immunosuppressive agents.3 Treatment administered early in the disease course may provide a more favorable outcome.11 Lesions characteristically heal with scarring and hyperpigmentation. Our case displayed more extensive involvement than has previously been reported. Our patient showed minimal improvement with topical therapy; however, he demonstrated thinning and regression of active lesions after 2 months of combined treatment with hydroxychloroquine and acitretin. Our use of oral pentoxifylline, hydroxychloroquine, and acitretin has not been previously reported in the other cases of AALP we reviewed. Acitretin is the only systemic agent for lichen planus that has achieved level A evidence, as it previously was shown to be highly effective in a placebo-controlled, double-blind study of 65 patients.12

Conclusion

Annular atrophic lichen planus is a known variant of lichen planus characterized by a loss of elastic fibers in the papillary dermis in the center of active lesions. Treatment with topical corticosteroids and phototherapy frequently is ineffective. To our knowledge, there are no studies to date regarding the efficacy of systemic therapy in treatment of AALP. Hydroxychloroquine and acitretin may prove to be beneficial treatment options for resistant AALP. Additional alternative treatments continue to be explored. We encourage reporting additional cases of AALP to further characterize its clinical presentation and response to treatments.

References
  1. Friedman DB, Hashimoto K. Annular atrophic lichen planus. J Am Acad Dermatol. 1991;25:392-394.
  2. James WD, Berger TG, Elston DM. Lichen planus and related conditions. In: James WD, Berger TG, Elston DM, eds. Andrews' Diseases of the Skin: Clinical Dermatology. 11th ed. China: Saunders Elsevier; 2011:213-215.  
  3. Kim BS, Seo SH, Jang BS, et al. A case of annular atrophic lichen planus. J Eur Acad Dermatol Venereol. 2007;21:989-990.
  4. Requena L, Olivares M, Pique E, et al. Annular atrophic lichen planus. Dermatology. 1994;189:95-98.
  5. Lipsker D, Piette JC, Laporte JL, et al. Annular atrophic lichen planus and Sneddon's syndrome. Dermatology. 1997;105:402-403.
  6. Mseddi M, Bouassadi S, Marrakchi S, et al. Annular atrophic lichen planus. Dermatology. 2003;207:208-209.
  7. Morales-Callaghan A Jr, Martinez G, Aragoneses H, et al. Annular atrophic lichen planus. J Am Acad Dermatol. 2005;52:906-908.
  8. Ponce-Olivera RM, Tirado-Sánchez A, Montes-de-Oca-Sánchez G, et al. Annular atrophic lichen planus. Int J Dermatol. 2007;46:490-491.
  9. Kim JS, Kang MS, Sagong C, et al. Annular atrophic lichen planus associated with hypertrophic lichen planus. Clin Exp Dermatol. 2008;33:195-197.
  10. Li B, Li JH, Xiao T, et al. Annular atrophic lichen planus. Eur J Dermatol. 2010;20:842-843.
  11. Sugashima Y, Yamamoto T. Annular atrophic lichen planus of the lip. Dermatol Online J. 2012;18:14.
  12. Manousaridis I, Manousaridis K, Peitsch WK, et al. Individualizing treatment and choice of medication in lichen planus: a step by step approach. J Dtsch Dermatol Ges. 2013;11:981-991.
References
  1. Friedman DB, Hashimoto K. Annular atrophic lichen planus. J Am Acad Dermatol. 1991;25:392-394.
  2. James WD, Berger TG, Elston DM. Lichen planus and related conditions. In: James WD, Berger TG, Elston DM, eds. Andrews' Diseases of the Skin: Clinical Dermatology. 11th ed. China: Saunders Elsevier; 2011:213-215.  
  3. Kim BS, Seo SH, Jang BS, et al. A case of annular atrophic lichen planus. J Eur Acad Dermatol Venereol. 2007;21:989-990.
  4. Requena L, Olivares M, Pique E, et al. Annular atrophic lichen planus. Dermatology. 1994;189:95-98.
  5. Lipsker D, Piette JC, Laporte JL, et al. Annular atrophic lichen planus and Sneddon's syndrome. Dermatology. 1997;105:402-403.
  6. Mseddi M, Bouassadi S, Marrakchi S, et al. Annular atrophic lichen planus. Dermatology. 2003;207:208-209.
  7. Morales-Callaghan A Jr, Martinez G, Aragoneses H, et al. Annular atrophic lichen planus. J Am Acad Dermatol. 2005;52:906-908.
  8. Ponce-Olivera RM, Tirado-Sánchez A, Montes-de-Oca-Sánchez G, et al. Annular atrophic lichen planus. Int J Dermatol. 2007;46:490-491.
  9. Kim JS, Kang MS, Sagong C, et al. Annular atrophic lichen planus associated with hypertrophic lichen planus. Clin Exp Dermatol. 2008;33:195-197.
  10. Li B, Li JH, Xiao T, et al. Annular atrophic lichen planus. Eur J Dermatol. 2010;20:842-843.
  11. Sugashima Y, Yamamoto T. Annular atrophic lichen planus of the lip. Dermatol Online J. 2012;18:14.
  12. Manousaridis I, Manousaridis K, Peitsch WK, et al. Individualizing treatment and choice of medication in lichen planus: a step by step approach. J Dtsch Dermatol Ges. 2013;11:981-991.
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