CNS/Brain Cancer
Feature
Glioblastoma: Prognosis is poor, but new therapies are emerging
Intensive, up-front treatment may help elderly patients with glioblastoma the most.
Conference Coverage
VIDEO: Immune therapy effective, durable in treatment-naive melanoma brain metastases
CHICAGO – For patients with asymptomatic brain metastases from melanoma who had not had prior treatment, nivolumab combined with ipilimumab...
Article
New approval lights up gliomas to aid resection
Gleolan received FDA approval on June 7.
Conference Coverage
VIDEO: Routine genomic testing identifies actionable alterations in 52% of tumors
CHICAGO – A trend was observed in longer overall survival among those patients who received recommended treatments.
Conference Coverage
VIDEO: TRK inhibitor shows 76% ORR across diverse cancers harboring TRK fusions
CHICAGO – Lead study investigator David Hyman, MD, discusses the integrated analysis of three larotrectinib trials and the drug’s regulatory...
Conference Coverage
Modifying CAR-T with IL-15 improved activity in glioma models
Adding an immunostimulatory cytokine to CAR-T improved the adaptive immunotherapy’s activity against aggressive pediatric brain malignancies.
Conference Coverage
Limit primary site radiation, but not craniospinal dose in medulloblastoma
BOSTON – Primary site irradiation in children with medulloblastoma can be limited to the tumor bed rather than the whole posterior fossa.
Case Reports
Dexamethasone-associated posterior reversible encephalopathy syndrome
Conference Coverage
Less cognitive decline with stereotactic radiosurgery after brain metastases resection
Key clinical point: Stereotactic radiosurgery following brain metastases resection was associated with similar survival but less toxicity than was...
News
FDA reports shortage of doxorubicin for injection, initiates importation
Conference Coverage
Heat shock protein peptide vaccine appears safe, effective for glioblastoma patients
Key clinical point: A heat shock protein peptide vaccine appears safe and effective for patients with glioblastoma in an early stage trial. Major...