CNS/Brain Cancer
Conference Coverage
Younger adults with brain metastases survive longer with radiosurgery alone
Major finding: Stereotactic radiosurgery was associated with significantly longer overall survival among patients age 50 years and younger (hazard...
News
Study indicates potential for longer survival after radiosurgery for brain metastases
Major finding: Median overall survival for patients with brain metastases from non–small cell lung cancer was 9.0 months for those treated with...
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Spare the hippocampus, preserve the memory in whole brain irradiation
Major finding: Patients who underwent whole brain radiation therapy with hippocampal avoidance had a 7% decline in delayed recall at 4 months,...
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Cranial radiotherapy for acute lymphoblastic leukemia linked to impaired neurocognition
Major finding: Compared with controls, survivors who had cranial radiotherapy had significant reductions in white matter integrity and lower...
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Lung cancer diagnosis aided by novel plasma protein
Major finding: IDH1 detection in plasma had a sensitivity and specificity of up to 82.9% and 76.6%, respectively.Data source: Prospective study of...
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Good survival rates with temozolomide CRT for high-risk, low-grade gliomas
Major finding: With temozolomide chemoradiotherapy, 3-year overall survival was 73% for patients with low-grade gliomas and three or more risk...
Conference Coverage
Donepezil fails to improve cognition after brain irradiation
Major finding: There were no significant differences between donepezil or placebo in either cognitive composite scores after 12 or 24 weeks of...
News
Frontline bevacizumab fails to boost glioblastoma survival in key trials
Major finding: Median overall survival for those assigned to radiation, temozolomide, and placebo was 16.1 months, vs.
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Bevacizumab plus irinotecan beats temozolomide in stalling glioblastoma
Major finding: The 6-month progression-free survival 6 months after randomization was 79.6% for patients treated with bevacizumab and irinotecan...
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Manage most SEGAs with rapamycin analogs, not surgery
Major finding: Rapamycin analogs shrink SEGA tumors by more than 50% in a majority of children, and obviate the need for surgery. Data source:...
News
Early Surgery Yields Survival Benefit for Low-Grade Gliomas
Major Finding: Overall mortality was 52% with watchful waiting and 32% with early resection; median survival was 5.9 years in the first group but...