Key clinical point: Findings from this real-life cohort of patients with early psoriatic arthritis (PsA) confirm the safety and efficacy of guselkumab on peripheral and axial manifestations.
Major finding: After 12 months of guselkumab treatment, the mean Patient Global Assessment ( P less than .0001), Visual Analogue Scale of Pain ( P less than .001), and Disease Activity Score of PsA ( P less than .0001) decreased significantly. Inflammatory low back pain disappeared as early as 24 weeks in all patients with concomitant axial disease. Low disease activity and remission were achieved by 65% and 35% of patients, respectively. No adverse events were reported.
Study details: The data come from an observational study involving 24 patients with early PsA who initiated therapy with guselkumab for severe skin involvement.
Disclosures: No specific funding was received for this study. The authors declared no conflicts of interest.
Source: Pantano I et al. Rheumatology (Oxford). 2021 Jun 21. doi: 10.1093/rheumatology/keab509.