Clinical Inquiries
Clinical Inquiries
Can CBT effectively treat adult insomnia disorder?
EVIDENCE-BASED ANSWER: Yes. Cognitive behavioral therapy (CBT) administered individually, in a group setting, or on the internet is effective for...
Clinical Inquiries
Does prophylactic azithromycin reduce the number of COPD exacerbations or hospitalizations?
EVIDENCE-BASED ANSWER: Yes for exacerbations, no for hospitalizations. Prophylactic azithromycin reduces the number of exacerbations by about 25...
Clinical Inquiries
How effective and safe is fecal microbial transplant in preventing C difficile recurrence?
EVIDENCE-BASED ANSWER: Fecal microbial transplant (FMT) is reasonably safe and effective. In patients who have had multiple Clostridium difficile...
Clinical Inquiries
Does niacin decrease cardiovascular morbidity and mortality in CVD patients?
EVIDENCE BASED ANSWER: No. Niacin doesn’t reduce cardiovascular disease (CVD) morbidity or mortality in patients with established disease (...
Clinical Inquiries
How well do POLST forms assure that patients get the end-of-life care they requested?
EVIDENCE-BASED ANSWER: Quite well, for cardiopulmonary resuscitation (CPR). Most patients (91%-100%) who select “do not resuscitate” (DNR) on...
Clinical Inquiries
What are the benefits and risks of daily low-dose aspirin for primary prevention of CV events?
EVIDENCE-BASED ANSWER: One nonfatal myocardial infarction (MI) will be avoided for every 126 to 138 adults who take daily aspirin for 10 years (...
Clinical Inquiries
Does exercise relieve vasomotor menopausal symptoms?
EVIDENCE-BASED ANSWER: No. Exercise doesn’t decrease the frequency or severity of vasomotor menopausal symptoms (VMS) in perimenopausal and...
Clinical Inquiries
Is megestrol acetate safe and effective for malnourished nursing home residents?
EVIDENCE-BASED ANSWER: No. Megestrol acetate (MA) is neither safe nor effective for stimulating appetite in malnourished nursing home residents....
Clinical Inquiries
How do oral NSAIDs compare to other oral analgesics right after an acute musculoskeletal injury?
EVIDENCE-BASED ANSWER: Nonsteroidal anti-inflammatory drugs (NSAIDs) are at least as effective as other oral analgesics (opioids, acetaminophen)...
Clinical Inquiries
How do hyaluronic acid and corticosteroid injections compare for knee OA relief?
EVIDENCE-BASED ANSWER: Inconsistent evidence shows a small amount of pain relief early (one week to 3 months) with corticosteroid (CS) injections...
Clinical Inquiries
Which interventions are effective in managing parental vaccine refusal?
EVIDENCE-BASED ANSWER: It’s unclear whether educational initiatives alone alter vaccine refusal. Although about a third of parents cite herd...