Clinical Inquiries
Clinical Inquiries
What are the risks of long-term PPI use for GERD symptoms in patients > 65 years?
EVIDENCE-BASED ANSWER: The use of proton pump inhibitors (PPIs) to control gastroesophageal reflux disease (GERD) is significantly associated with...
Clinical Inquiries
Is intra-articular platelet-rich plasma injection an effective treatment for knee OA?
EVIDENCE-BASED ANSWER: Probably not, based on the balance of evidence. While low-quality evidence may suggest potential benefit,...
Clinical Inquiries
Does left atrial appendage closure reduce stroke rates as well as oral anticoagulants and antiplatelet meds in A-fib patients?
EVIDENCE-BASED ANSWER: Yes. Left atrial appendage closure (LAAC) with the Watchman device is noninferior to vitamin K antagonists (VKAs) and non-...
Clinical Inquiries
Does amniotomy shorten spontaneous labor or improve outcomes?
EVIDENCE-BASED ANSWER: No. Amniotomy neither shortens spontaneous labor nor improves any of the following outcomes: length of first stage of labor...
Clinical Inquiries
What medical therapies work for gastroparesis?
EVIDENCE-BASED ANSWER: It’s unclear if there are any highly effective medications for gastroparesis (TABLE1-10). Metoclopramide...
Clinical Inquiries
What’s the best VTE treatment for patients with cancer?
EVIDENCE-BASED ANSWER: No head-to-head studies directly compare all the main treatments for venous thromboembolism (VTE) in cancer patients. Long-...
Clinical Inquiries
How effectively do ACE inhibitors and ARBs prevent migraines?
EVIDENCE-BASED ANSWER: The angiotensin-converting enzyme (ACE) inhibitor lisinopril reduces the number of migraines by about 1.5 per month in...
Clinical Inquiries
How often does long-term PPI therapy cause clinically significant hypomagnesemia?
EVIDENCE-BASED ANSWER: Rarely. Proton pump inhibitors (PPIs) may be associated with decreases in serum magnesium laboratory...
Clinical Inquiries
Do statins alter the risk or progression of dementia?
EVIDENCE-BASED SUMMARY: No. Moderate-intensity statin therapy (with pravastatin or simvastatin) doesn’t prevent progression to dementia in...
Clinical Inquiries
What’s the best secondary treatment for patients who fail initial triple therapy for H pylori?
EVIDENCE-BASED ANSWER: Treating patients with Helicobacter pylori infection who have failed clarithromycin-based triple therapy with either...
Clinical Inquiries
What are the benefits/risks of giving betamethasone to women at risk of late preterm labor?
EVIDENCE-BASED ANSWER: Giving betamethasone to women at risk for delivery between 34 weeks 0 days and 36 weeks 6 days can lower by almost 40% the...