Clinical Inquiries

Clinical Inquiries

How does gender-affirming hormone therapy affect QOL in transgender patients?

Author:

Sarah Wilhelm, MD

Gary Kelsberg, MD

Sarah Safranek, MLIS

EVIDENCE-BASED ANSWER: There are modest effects on depression but not anxiety. ­Gender-affirming hormone therapy (GAHT) is associated with modest...

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Clinical Inquiries

How accurate is transcutaneous bilirubin testing in newborns with darker skin tones?

Author:

Brandi Boden, DO

Brittany Buescher, MD

Amanda Kim, MD

Jon O. Neher, MD

Sarah Safranek, MLIS

EVIDENCE-BASED ANSWER: Fairly accurate. Photometric transcutaneous bilirubin (TcB) testing may overestimate total serum bilirubin (TSB) in...

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Clinical Inquiries

Does an early COPD diagnosis improve long-term outcomes?

Author:

Dan Bernet, MD

Charles Randolph, MD

Jon O. Neher, MD

Sarah Safranek, MLIS

EVIDENCE-BASED ANSWER: It depends. A diagnosis of chronic obstructive pulmonary disease (COPD) made using screening spirometry in patients without...

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Clinical Inquiries

What barriers delay treatment in patients with hepatitis C?

Author:

Kimberly Crosby, PharmD

Simone Bigelow, DO

Viviane Sachs, MD

Jennifer Weakley, MD

Helga Skaftason, MD, MPH

Toni Hoberecht, MA, MLIS, AHIP

EVIDENCE-BASED ANSWER: Multiple patient-specific and provider-perceived factors delay initiation of treatment in patients with hepatitis C....

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Clinical Inquiries

Do behavioral interventions improve nighttime sleep in children < 1 year old?

Author:

Morgan Hungenberg, DO

Breanna Houss, MD

Madhav Narayan, MD

Corey Lyon, DO

Kristen DeSanto, MSLS, MS, RD

EVIDENCE-BASED ANSWER: YES. Infants respond to behavioral interventions, although objective data are limited. Behavioral interventions include...

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Clinical Inquiries

Are antipsychotics effective adjunctive Tx for patients with moderate-to-severe depression?

Author:

Heather Bleacher, MD, MPH

Lindsay Koerperich, MD

Naomi Malam, MD, MSPH

Kristen DeSanto, MSLS, MS, RD

EVIDENCE-BASED ANSWER: YES. Augmentation with second- generation antipsychotics, especially aripiprazole and quetiapine, appears to be effective...

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Clinical Inquiries

Is nonoperative treatment effective for acute Achilles tendon rupture?

Author:

Sabrina Silver, DO, CAQSM

Stephanie Fulleborn, MD

Nolan Feola, MD

Sydney Giblin, MD

EVIDENCE-BASED ANSWER: YES. Nonoperative and open sur- gical interventions provide equal long-term functional outcomes of the affected Achilles...

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Clinical Inquiries

Does platelet-rich plasma improve patellar tendinopathy symptoms?

Author:

Emily Wolfenden, MD, MPH

Brian Vukelic, MD

Matthew DeMarco, MD

Jordan Knox, MD

Dominik Ose, DrPH, MPH

EVIDENCE-BASED ANSWER: IT’S UNCLEAR. High-quality data have not consistently established the effectiveness of platelet-rich plasma (PRP)...

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Clinical Inquiries

Is bicarbonate therapy effective in preventing CKD progression?

Author:

Haris Ahmad, DO

Theresa Wertin, MD

Yilin Zhang, MD

Jon O. Neher, MD

Beth Auten, MA, MSLIS, AHIP

EVIDENCE-BASED ANSWER: YES. Long-term sodium bicarbonate therapy slightly slows the loss of renal function in patients with chronic kidney disease...

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Clinical Inquiries

Does adjunctive oxytocin infusion during balloon cervical ripening improve labor induction?

Author:

Rachel Dubay, MD

Nicola Rentschler, MD

Dara Jolly, MD

Jon O. Neher, MD

Sarah Safranek, MLIS

EVIDENCE-BASED ANSWER: YES. Compared to the use of a transcervical balloon alone, combined cervical ripening with a balloon catheter and oxytocin...

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Clinical Inquiries

Are SERMs safe and effective for the treatment of hypogonadism in men?

Author:

Tina Joseph, DO

Lawrence M. Gibbs, MD, MSED, FAAFP

Kim Pham, DO

EVIDENCE-BASED ANSWER: YES. For both normal-weight and obese men with low testosterone levels and hypogonadal symptoms, selective estrogen...

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