Clinical Inquiries
Clinical Inquiries
What is the best treatment for wrist ganglion cysts?
EVIDENCE-BASED ANSWER: Open surgical excision of wrist ganglion cysts is associated with a lower recurrence rate than aspiration with or without...
Clinical Inquiries
Do group visits improve HbA1c more than individual visits in patients with T2DM?
EVIDENCE-BASED ANSWER: Yes. In patients with type 2 diabetes mellitus (T2DM), group visits led by health professionals or teams improved...
Clinical Inquiries
Does using e-cigarettes increase cigarette smoking in adolescents?
EVIDENCE-BASED ANSWER: Probably. Electronic cigarette (e-cigarette) use by adolescents is associated with a 2- to 4-fold increase in cigarette...
Clinical Inquiries
Does tranexamic acid reduce mortality in women with postpartum hemorrhage?
EVIDENCE-BASED ANSWER: Yes. When used in conjunction with the standard of care, 1 g intravenous (IV) tranexamic acid given 1 to 3 hours after...
Clinical Inquiries
Time to conception after miscarriage: How long to wait?
EVIDENCE-BASED ANSWER: An interpregnancy interval (IPI) of < 6 months following miscarriage is associated with an increased live birth rate in...
Clinical Inquiries
How safe and effective is ondansetron for nausea and vomiting in pregnancy?
EVIDENCE-BASED ANSWER: Oral ondansetron is more effective than a combination of pyridoxine and doxylamine for outpatient treatment of nausea and...
Clinical Inquiries
Which oral nonopioid agents are most effective for OA pain?
EVIDENCE-BASED ANSWER: Nonsteroidal anti-inflammatory drugs (NSAIDs), when used at the maximum clinically effective dose, reduce osteoarthritis (...
Clinical Inquiries
Can unintended pregnancies be reduced by dispensing a year’s worth of hormonal contraception?
EVIDENCE-BASED ANSWER: Probably, although studies that looked directly at this outcome are limited. A systematic review showed that women who...
Clinical Inquiries
Do A-fib patients continue to benefit from vitamin K antagonists with advancing age?
EVIDENCE-BASED ANSWER: Yes, patients with atrial fibrilla- tion who are between the ages of 50 and 90 years continue to benefit from vitamin K...
Clinical Inquiries
How effective is spironolactone for treating resistant hypertension?
EVIDENCE-BASED ANSWER: Very effective. Spironolactone reduces systolic blood pressure (SBP) by 11 to 17 mm Hg and diastolic blood pressure (DBP)...
Clinical Inquiries
Does withholding an ACE inhibitor or ARB before surgery improve outcomes?
EVIDENCE-BASED ANSWER: A guarded yes, because the evidence of benefit is from observational studies and applies to noncardiac surgery. Withholding...