Clinical Inquiries

Clinical Inquiries

Is the incidence of depressive disorders increased following cerebral concussion?

Author:

Jason W. Deck, MD

Thomas Kern, MD

Lamont Cavanagh, MD

Matthew Bartow, DO

Franklin T. Perkins III, MD

Toni Hoberecht, MA, MLIS, AHIP

Alyssa Migdalski, MLIS

EVIDENCE-BASED ANSWER: Yes, in some populations. Youth and adolescents with self-reported history of concussion had increased risk of depressive...

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Clinical Inquiries

Does XR injectable naltrexone prevent relapse as effectively as daily sublingual buprenorphine-naloxone?

Author:

Matthew Roe, MD

Courtenay Gilmore Wilson, PharmD, BCPS, BCACP, CDE, CPP

Carriedelle Wilson Fusco, FNP-BC

Stephen Hulkower, MD

Sue Stigleman, MLS

EVIDENCE-BASED ANSWER: Yes. Monthly extended-release injectable naltrexone (XR-NTX) treats opioid use disorder as effectively as daily sublingual...

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Clinical Inquiries

Do electronic reminder systems help patients with T2DM to lose weight?

Author:

William Kwan, MD

Jon O. Neher, MD

Sarah Safranek, MLIS

EVIDENCE-BASED ANSWER: PROBABLY NOT—but they may augment self-management. Four-component telehealth systems—including electronic reminders,...

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Clinical Inquiries

Does early introduction of peanuts to an infant’s diet reduce the risk for peanut allergy?

Author:

Greg Jungwirth, MD

Kevin Stock, PharmD

Jon O. Neher, MD

Sarah Safranek, MLIS

EVIDENCE-BASED ANSWER: Probably not, unless the child has severe eczema or egg allergy. In a general pediatric population, introducing peanuts...

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Clinical Inquiries

Does evidence support the use of supplements to aid in BP control?

Author:

Lawrence M. Gibbs, MD, MSEd

Rajasree J. Nair, MD

Joan Nashelsky, MLS

EVIDENCE-BASED ANSWER: Yes. A number of well-tolerated natural therapies have been shown to reduce systolic and diastolic blood pressure (BP). (...

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Clinical Inquiries

Which medications work best for menorrhagia?

Author:

Allison Lale, MD, MPH

Elise Halajian, DO

Rick Guthmann, MD, MPH

Joan Nashelsky, MLS

EVIDENCE-BASED ANSWER: Four medications have been shown to reduce ­menstrual blood loss (MBL) significantly in ­placebo-controlled randomized...

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Clinical Inquiries

Does concurrent use of clopidogrel and PPIs increase CV risk in patients with ACS?

Author:

Sandy Shehata, PharmD

Jason Baker, MD

Gary Kelsberg, MD

Sarah Safranek, MLIS

EVIDENCE-BASED ANSWER: No. Adding a proton pump inhibitor (PPI) in patients taking antiplatelet medications such as clopidogrel for acute coronary...

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Clinical Inquiries

Do cinnamon supplements improve glycemic control in adults with T2DM?

Author:

Beth Careyva, MD

Grant Greenberg, MD, MA, MHSA

Katarzyna Jabbour, PharmD, BCPS

Nicole Defenbaugh, PhD

Joan Nashelsky, MLS

EVIDENCE-BASED ANSWER: The answer isn’t clear. Cinnamon supplements for adults with type 2 diabetes haven’t been shown to decrease hemoglobin A1C...

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Clinical Inquiries

Does vitamin D supplementation reduce asthma exacerbations?

Author:

Jaspreet Jaura, MD

Gary Kelsberg, MD

Sarah Safranek, MLIS

EVIDENCE-BASED ANSWER: Yes, to some extent it does, and primarily in patients with low vitamin D levels. Supplementation reduces asthma...

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Clinical Inquiries

Do prophylactic antipyretics reduce vaccination-associated symptoms in children?

Author:

Hang Chau-Glendinning, DO

Blair Baber, PharmD

Jon O. Neher, MD

Sarah Safranek, MLIS

EVIDENCE-BASED ANSWER: Yes for acetaminophen, not so much for ibuprofen. Prophylactic acetaminophen reduces the odds of febrile reactions in the...

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Clinical Inquiries

Does screening by primary care providers effectively detect melanoma and other skin cancers?

Author:

Jenna Madeja, DO

Gary Kelsberg, MD

Sarah Safranek, MLIS

EVIDENCE-BASED ANSWER: Possibly. No trials have directly assessed detection of melanoma and other skin cancers by primary care providers.

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